This study used human DNA structure to inspire an innovative design concept. Mechanical testing assessed how design parameters and thermal shock cycles affected it. As thermal shock cycles increase, material characteristics decrease. After sixty thermal shock cycles, tensile and flexural strengths dropped 43.33% and 35.90%, respectively. DNA structures had a better strength-to-weight ratio than solids. After 60 thermal shock cycles, 2 mm ribs, straight ribs, and hexagonal honeycomb ribs had higher tensile and flexural strengths of 9.42 and 20.76 MPa, respectively.