Torque Teno Virus: A Promising Biomarker in Kidney Transplant Recipients

被引：1

作者：

Dal Lago, Sara ^{[1
]}

Brani, Paola ^{[2
]}

Ietto, Giuseppe ^{[2
]}

Dalla Gasperina, Daniela ^{[2
]}

Gianfagna, Francesco ^{[3
,4
]}

Giaroni, Cristina ^{[2
]}

Bosi, Annalisa ^{[3
]}

Ferrante, Francesca Drago ^{[5
]}

Genoni, Angelo ^{[2
]}

Manzoor, Hafza Zahira ^{[2
]}

Ambrosini, Andrea ^{[1
]}

De Cicco, Marco ^{[1
]}

Quartarone, Corradina Dina ^{[1
]}

Khemara, Sara ^{[1
]}

Carcano, Giulio ^{[2
]}

Maggi, Fabrizio ^{[6
]}

Baj, Andreina ^{[2
]}

机构：

[1] Univ Insubria, Nephrol Dept, ASST Sette Laghi, I-21100 Varese, Italy

[2] Univ Insubria, Dept Med & Technol Innovat, I-21100 Varese, Italy

[3] Univ Insubria, Dept Med & Surg, I-21100 Varese, Italy

[4] Mediterranea Cardioctr, I-80122 Naples, Italy

[5] ASST Sette Laghi, Lab Microbiol, I-21100 Varese, Italy

[6] IRCCS, Lab Virol, Natl Inst Infect Dis L Spallanzani, I-00149 Rome, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 14期

关键词：

Torque Teno Virus; anellovirus; immunosuppression; kidney transplantation; immunosuppressive therapy; infection; CYTOMEGALOVIRUS-INFECTION; HUMAN VIROME; TTV; IMMUNOSUPPRESSION; LOAD; TORQUETENOVIRUS; TACROLIMUS; MANAGEMENT; KINETICS; DIALYSIS;

D O I：

10.3390/ijms25147744

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Torque Teno Virus (TTV) is a ubiquitous component of the human virome, not associated with any disease. As its load increases when the immune system is compromised, such as in kidney transplant (KT) recipients, TTV load monitoring has been proposed as a method to assess immunosuppression. In this prospective study, TTV load was measured in plasma and urine samples from 42 KT recipients, immediately before KT and in the first 150 days after it. Data obtained suggest that TTV could be a relevant marker for evaluating immune status and could be used as a guide to predict the onset of infectious complications in the follow-up of KT recipients. Since we observed no differences considering distance from transplantation, while we found a changing trend in days before viral infections, we suggest to consider changes over time in the same subjects, irrespective of time distance from transplantation.

引用

页数：15

共 50 条

[1] Smoking, Alcohol Intake and Torque Teno Virus in Stable Kidney Transplant Recipients
Doorenbos, Caecilia S. E.
Jonker, Jip
Hao, Jiasi
Gore, Edmund J.
Kremer, Daan
Knobbe, Tim J.
de Joode, Anoek A. E.
Sanders, Jan Stephan F.
Thaunat, Olivier
Niesters, Hubert G. M.
Van Leer-Buter, Coretta C.
Bakker, Stephan J. L.
VIRUSES-BASEL, 2023, 15 (12):
[2] Torque Teno Virus Loads as a Marker of Immunosuppression in Pediatric Kidney Transplant Recipients
Kelly, Ellen
Awan, Atif
Sweeney, Clodagh
Wildes, Dermot
De Gascun, Cillian
Hassan, Jaythoon
Riordan, Michael
PEDIATRIC TRANSPLANTATION, 2024, 28 (07)
[3] QUANTIFICATION OF TORQUE TENO VIRUS VIRAEMIA AS A PROSPECTIVE BIOMARKER FOR INFECTIOUS DISEASE IN KIDNEY ALLOGRAFT RECIPIENTS
Strassl, R.
Schiemann, M.
Doberer, K.
Goerzer, I.
Puchhammer-Stoeckl, E.
Eskandary, F.
Kikic, Z.
Gualdoni, G. A.
Vossen, M. G.
Rasoul-Rockenschaub, S.
Herkner, H.
Boehmig, G. A.
Bond, G.
TRANSPLANT INTERNATIONAL, 2018, 31 : 16 - 16
[4] Quantification of Torque Teno Virus Viremia as a Prospective Biomarker for Infectious Disease in Kidney Allograft Recipients
Strassl, Robert
Schiemann, Martin
Doberer, Konstantin
Goerzer, Irene
Puchhammer-Stoeckl, Elisabeth
Eskandary, Farsad
Kikic, Zeljko
Gualdoni, Guido A.
Vossen, Mathias G.
Rasoul-Rockenschaub, Susanne
Herkner, Harald
Boehmig, Georg A.
Bond, Gregor
JOURNAL OF INFECTIOUS DISEASES, 2018, 218 (08): : 1191 - 1199
[5] Evaluation of Torque Teno Virus DNA Load as a Predictive Biomarker in Kidney Transplant Recipients Converted from Calcineurin Inhibitors to Belatacept
Cabezas, Lara
Truffot, Aurelie
Germi, Raphaele
Bugnazet, Mathilde
Malvezzi, Paolo
Gnesotto, Manon
Rostaing, Lionel
Jouve, Thomas
Noble, Johan
KIDNEY INTERNATIONAL REPORTS, 2024, 9 (06): : 1718 - 1729
[6] The Effect of Tacrolimus and Mycophenolic Acid on Torque Teno Virus Loads in Kidney Transplant Recipients.
van Rijn, A.
Meziyerh, S.
van der Helm, D.
van Gelder, T.
Kroes, A.
de Fijter, J.
Moes, D.
Rotmans, J.
de Vries, A.
Feltkamp, M.
AMERICAN JOURNAL OF TRANSPLANTATION, 2022, 22 : 1030 - 1030
[7] Torque Teno Virus for Risk Stratification of Acute Biopsy-Proven Alloreactivity in Kidney Transplant Recipients
Strassl, Robert
Doberer, Konstantin
Rasoul-Rockenschaub, Susanne
Herkner, Harald
Goerzer, Irene
Klaeger, Johannes Philipp
Schmidt, Ralf
Haslacher, Helmuth
Schiemann, Martin
Eskandary, Farsad A.
Kikic, Zeljko
Reindl-Schwaighofer, Roman
Puchhammer-Stockl, Elisabeth
Boehmig, Georg A.
Bond, Gregor
JOURNAL OF INFECTIOUS DISEASES, 2019, 219 (12): : 1934 - 1939
[8] Dynamics of torque teno virus load in kidney transplant recipients with indication biopsy and therapeutic modifications of immunosuppression
Reineke, Marvin
Morath, Christian
Speer, Claudius
Rudek, Markus
Bundschuh, Christian
Klein, Julian A. F.
Mahler, Christoph F.
Kaelble, Florian
Nusshag, Christian
Beimler, Joerg
Zeier, Martin
Bartenschlager, Ralf
Schnitzler, Paul
Benning, Louise
FRONTIERS IN MEDICINE, 2024, 11
[9] High-Density Lipoprotein Particles and Torque Teno Virus in Stable Outpatient Kidney Transplant Recipients
Jonker, Jip
Doorenbos, Caecilia S. E.
Kremer, Daan
Gore, Edmund J.
Niesters, Hubert G. M.
van Leer-Buter, Coretta
Bourgeois, Philippe
Connelly, Margery A.
Dullaart, Robin P. F.
Berger, Stefan P.
Sanders, Jan-Stephan F.
Bakker, Stephan J. L.
VIRUSES-BASEL, 2024, 16 (01):
[10] Torque Teno Virus Load Is Associated With Subclinical Alloreactivity in Kidney Transplant Recipients: A Prospective Observational Trial
Doberer, Konstantin
Haupenthal, Frederik
Nackenhorst, Maja
Bauernfeind, Florian
Dermuth, Florentina
Eigenschink, Michael
Schiemann, Martin
Klaeger, Johannes
Goerzer, Irene
Eskandary, Farsad
Reindl-Schwaighofer, Roman
Kikic, Zeljko
Boehmig, Georg
Strassl, Robert
Regele, Heinz
Puchhammer-Stoeckl, Elisabeth
Bond, Gregor
TRANSPLANTATION, 2021, 105 (09) : 2112 - 2118

← 1 2 3 4 5 →