Bone Marrow Adipose Tissue as a Critical Regulator of Postmenopausal Osteoporosis - A Concise Review

被引：1
|
作者：
Niu, Huifang [1 ,2 ]
Zhou, Minfeng [1 ]
Xu, Xiaoyun [2 ]
Xu, Xiaojuan [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Wuhan, Hubei, Peoples R China
[2] Huazhong Agr Univ, Sch Food Sci & Technol, Key Lab Environm Correlat Dietol,Minist Educ, Hubei Key Lab Fruit Vegetable Proc Qual Control, Wuhan, Hubei, Peoples R China
来源：
CLINICAL INTERVENTIONS IN AGING | 2024年 / 19卷
基金：
中国国家自然科学基金;
关键词：
postmenopausal osteoporosis; bone marrow adipose tissue; bone metabolism; immune system; cytokines; ESTROGEN-RECEPTOR-ALPHA; MESENCHYMAL STEM-CELLS; TUMOR-NECROSIS-FACTOR; AGE-RELATED-CHANGES; ADIPOCYTE LIPOTOXICITY; INSULIN-RESISTANCE; METABOLIC SYNDROME; HUMAN OSTEOBLASTS; ZOLEDRONIC ACID; ADIPONECTIN;
D O I：
10.2147/CIA.S466446
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Postmenopausal osteoporosis (PMOP) is a major health problem affecting millions of women worldwide. PMOP patients are often accompanied by abnormal accumulation of bone marrow adipose tissue (BMAT). BMAT is a critical regulator of bone homeostasis, and an increasing BMAT volume is negatively associated with bone mass reduction or fracture. BMAT regulates bone metabolism via adipokines, cytokines and the immune system, but the specific mechanisms are largely unknown. This review emphasizes the impact of estrogen deficiency on bone homeostasis and BMAT expansion, and the mechanism by which BMAT regulates PMOP, providing a promising strategy for targeting BMAT in preventing and treating PMOP.
引用
收藏
页码：1259 / 1272
页数：14
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