Visible-Light Photoredox-Catalyzed Difunctionalization of Alkynes with Quinoxalin-2(1H)-Ones, P4S10, and Alcohols

被引：2

作者：

Song, Lianhui ^{[1
]}

Ma, Chao ^{[1
]}

Huang, Jian ^{[1
]}

Lv, Yufen ^{[1
]}

Yue, Huilan ^{[2
,3
]}

You, Jinmao ^{[1
,4
]}

Wei, Wei ^{[1
]}

Yi, Dong ^{[5
]}

机构：

[1] Qufu Normal Univ, Sch Chem & Chem Engn, Key Lab Catalyt Convers & Clean Energy Univ Shando, Qufu 273165, Shandong, Peoples R China

[2] Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China

[3] Northwest Inst Plateau Biol, CAS Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China

[4] Shaoxing Univ, Coll Chem & Chem Engn, Shaoxing 312000, Peoples R China

[5] Southwest Med Univ, Sch Pharm, Green Pharmaceut Technol Key Lab Luzhou City, Luzhou 646000, Sichuan, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 15期

基金：

中国国家自然科学基金;

关键词：

3-COMPONENT REACTION; HYPERVALENT IODINE; REACTIVITY; ARYLATION; TRIFLUOROMETHYLATION; FUNCTIONALIZATION; ACID;

D O I：

10.1021/acs.joc.4c01409

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Visible-light photoredox-catalyzed method has been developed for the synthesis of quinoxalin-2(1H)-one-containing vinyl phosphorodithioates via direct difunctionalization of alkynes with quinoxalin-2(1H)-ones, P4S10 and alcohols. This four-component reaction could be carried out under metal-free and mild conditions, affording a number of quinoxalin-2(1H)-one-containing vinyl phosphorodithioates in moderate to good yields with Z-isomers as the major products. Photocatalytic radical mechanism is proposed based on the results of radical trapping and fluorescence quenching experiments.

引用

页码：10974 / 10986

页数：13

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