Consensus Guidance for Monitoring Individuals With Islet Autoantibody-Positive Pre-Stage 3 Type 1 Diabetes

被引：18

作者：

Phillip, Moshe ^{[1
,2
]}

Achenbach, Peter ^{[3
,4
]}

Addala, Ananta ^{[5
,6
]}

Albanese-O'Neill, Anastasia ^{[7
]}

Battelino, Tadej ^{[8
,9
]}

Bell, Kirstine J. ^{[10
,11
]}

Besser, Rachel E. J. ^{[12
,13
]}

Bonifacio, Ezio ^{[14
,15
,16
]}

Colhoun, Helen M. ^{[17
,18
]}

Couper, Jennifer J. ^{[19
,20
,21
]}

Craig, Maria E. ^{[10
,11
,22
]}

Danne, Thomas ^{[23
]}

de Beaufort, Carine ^{[24
,25
,26
]}

Dovc, Klemen ^{[8
,9
]}

Driscoll, Kimberly A. ^{[27
,28
,29
]}

Dutta, Sanjoy ^{[30
]}

Ebekozien, Osagie ^{[31
]}

Larsson, Helena Elding ^{[32
,33
,34
]}

Feiten, Daniel J. ^{[35
]}

Frohnert, Brigitte I. ^{[27
]}

Gabbay, Robert A. ^{[36
]}

Gallagher, Mary P. ^{[37
]}

Greenbaum, Carla J. ^{[38
]}

Griffin, Kurt J. ^{[39
,40
]}

Hagopian, William ^{[41
]}

Haller, Michael J. ^{[29
,42
]}

Hendrieckx, Christel ^{[43
,44
,45
]}

Hendriks, Emile ^{[46
,47
]}

Holt, Richard I. G. ^{[48
,49
]}

Hughes, Lucille ^{[50
]}

Ismail, Heba M. ^{[51
]}

Jacobsen, Laura M. ^{[42
]}

Johnson, Suzanne B. ^{[52
]}

Kolb, Leslie E. ^{[53
]}

Kordonouri, Olga ^{[23
]}

Lange, Karin ^{[54
]}

Lash, Robert W. ^{[55
]}

Lernmark, Ake ^{[32
]}

Libman, Ingrid ^{[56
]}

Lundgren, Markus ^{[32
,57
]}

Maahs, David M. ^{[5
]}

Marcovecchio, M. Loredana ^{[58
]}

Mathieu, Chantal ^{[59
]}

Miller, Kellee M. ^{[31
]}

O'Donnell, Holly K. ^{[27
]}

Oron, Tal ^{[1
,2
]}

Patil, Shivajirao P. ^{[60
]}

Pop-Busui, Rodica ^{[61
]}

Rewers, Marian J. ^{[27
]}

Rich, Stephen S. ^{[62
]}

机构：

[1] Schneider Childrens Med Ctr Israel, Natl Ctr Childhood Diabet, Inst Endocrinol & Diabet, Petah Tiqwa, Israel

[2] Tel Aviv Univ, Fac Med & Hlth Sci, Tel Aviv, Israel

[3] Helmholtz Zentrum Munchen, Inst Diabet Res, German Res Ctr Environm Hlth, Munich Neuherberg, Germany

[4] Tech Univ Munich, Klinikum Rechts Isar, Forschergrp Diabet, Munich, Germany

[5] Stanford Univ, Sch Med, Div Endocrinol, Dept Pediat, Stanford, CA USA

[6] Stanford Univ, Stanford Diabet Res Ctr, Sch Med, Stanford, CA USA

[7] Breakthrough T1D, Gainesville, FL 32611 USA

[8] Univ Ljubljana, Fac Med, Ljubljana, Slovenia

[9] Univ Med Ctr Ljubljana, Dept Endocrinol Diabet & Metab, Ljubljana, Slovenia

[10] Univ Sydney, Charles Perkins Ctr, Sydney, NSW, Australia

[11] Univ Sydney, Fac Med & Hlth, Sydney, NSW, Australia

[12] Univ Oxford, Oxford Natl Inst Hlth & Care Res, Biomed Res Ctr, Nuffield Dept Med,JDRF Wellcome Diabet & Inflammat, Oxford, England

[13] Univ Oxford, Dept Paediat, Oxford, England

[14] Tech Univ Dresden, Fac Med, Ctr Regenerat Therapies Dresden, Dresden, Germany

[15] Tech Univ Dresden, Paul Langerhans Inst Dresden, Helmholtz Ctr Munich, Univ Clin Carl Gustav Carus, Dresden, Germany

[16] Tech Univ Dresden, Fac Med, Dresden, Germany

[17] Univ Edinburgh, Inst Genet & Canc, Edinburgh, Scotland

[18] NHS Fife, Dept Publ Hlth, Kirkcaldy, Scotland

[19] Univ Adelaide, Robinson Res Inst, Adelaide, SA, Australia

[20] Univ Adelaide, Adelaide Med Sch, Adelaide, SA, Australia

[21] Womens & Childrens Hosp, Div Paediat, Adelaide, SA, Australia

[22] UNSW Med & Hlth, Sch Clin Med, Discipline Paediat & Child Hlth, Sydney, NSW, Australia

[23] Breakthrough T1D, Lisbon, Portugal

[24] Int Soc Pediat & Adolescent Diabet ISPAD, Berlin, Germany

[25] Ctr Hosp CH Luxembourg, Clin Pediat, Diabet & Endocrine Care Clin Pediat DECCP, Luxembourg City, Luxembourg

[26] Univ Luxembourg, Fac Sci Technol & Med, Esch Belval, Luxembourg

[27] Univ Colorado, Dept Pediat, Barbara Davis Ctr Diabet, Anschutz Med Campus, Aurora, CO USA

[28] Univ Florida, Dept Clin & Hlth Psychol, Gainesville, FL USA

[29] Univ Florida, Diabet Inst, Dept Pediat, Gainesville, FL USA

[30] Breakthrough T1D, New York, NY USA

[31] T1D Exchange, Boston, MA USA

[32] Lund Univ, Dept Clin Sci, Lund, Sweden

[33] Skane Univ Hosp, Dept Pediat, Malmo, Sweden

[34] Skane Univ Hosp, Dept Pediat, Lund, Sweden

[35] Childrens Diabet Fdn, Aurora, CO USA

[36] Amer Diabet Assoc, Arlington, VA USA

[37] NYU Langone Med Ctr, New York, NY USA

[38] Benaroya Res Inst, Ctr Intervent Immunol & Diabet Program, Seattle, WA USA

[39] Sanford Res, Sioux Falls, SD USA

[40] Univ South Dakota, Sanford Sch Med, Dept Pediat, Sioux Falls, SD USA

[41] Univ Washington, Pacific Northwest Diabet Res Inst, Seattle, WA USA

[42] Univ Florida, Coll Med, Div Endocrinol, Gainesville, FL USA

[43] Deakin Univ, Sch Psychol, Geelong, Vic, Australia

[44] Australian Ctr Behav Res Diabet, Diabet Victoria, Carlton, Vic, Australia

[45] Deakin Univ, Inst Hlth Transformat, Geelong, Vic, Australia

[46] Univ Cambridge, Dept Paediat, Cambridge, England

[47] Cambridge Univ Hosp NHS Fdn Trust, Cambridge, England

[48] Univ Southampton, Fac Med, Human Dev & Hlth, Southampton, England

[49] Univ Hosp Southampton NHS Fdn Trust, Natl Inst Hlth & Care Res, Biomed Res Ctr, Southampton, England

[50] Mt Sinai South Nassau, Oceanside, NY USA

来源：

DIABETES CARE | 2024年 / 47卷 / 08期

关键词：

DISEASE-MODIFYING THERAPY; BETA-CELL AUTOIMMUNITY; 1ST; YEARS; CLINICAL CHARACTERISTICS; ENVIRONMENTAL DETERMINANTS; PSYCHOLOGICAL IMPACT; GLYCEMIC CONTROL; YOUNG-CHILDREN; C-PEPTIDE; HIGH-RISK;

D O I：

10.2337/dci24-0042

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Given the proven benefits of screening to reduce diabetic ketoacidosis (DKA) likelihood at the time of stage 3 type 1 diabetes diagnosis, and emerging availability of therapy to delay disease progression, type 1 diabetes screening programs are being increasingly emphasized. Once broadly implemented, screening initiatives will identify significant numbers of islet autoantibody-positive (IAb(+)) children and adults who are at risk for (confirmed single IAb(+)) or living with (multiple IAb(+)) early-stage (stage 1 and stage 2) type 1 diabetes. These individuals will need monitoring for disease progression; much of this care will happen in nonspecialized settings. To inform this monitoring, JDRF, in conjunction with international experts and societies, developed consensus guidance. Broad advice from this guidance includes the following: 1) partnerships should be fostered between endocrinologists and primary care providers to care for people who are IAb(+); 2) when people who are IAb(+) are initially identified, there is a need for confirmation using a second sample; 3) single IAb(+) individuals are at lower risk of progression than multiple IAb(+) individuals; 4) individuals with early-stage type 1 diabetes should have periodic medical monitoring, including regular assessments of glucose levels, regular education about symptoms of diabetes and DKA, and psychosocial support; 5) interested people with stage 2 type 1 diabetes should be offered trial participation or approved therapies; and 6) all health professionals involved in monitoring and care of individuals with type 1 diabetes have a responsibility to provide education. The guidance also emphasizes significant unmet needs for further research on early-stage type 1 diabetes to increase the rigor of future recommendations and inform clinical care.

引用

页数：24

共 50 条

[1] Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes
Phillip, Moshe
Achenbach, Peter
Addala, Ananta
Albanese-O'Neill, Anastasia
Battelino, Tadej
Bell, Kirstine J.
Besser, Rachel E. J.
Bonifacio, Ezio
Colhoun, Helen M.
Couper, Jennifer J.
Craig, Maria E.
Danne, Thomas
de Beaufort, Carine
Dovc, Klemen
Driscoll, Kimberly A.
Dutta, Sanjoy
Ebekozien, Osagie
Larsson, Helena Elding
Feiten, Daniel J.
Frohnert, Brigitte I.
Gabbay, Robert A.
Gallagher, Mary P.
Greenbaum, Carla J.
Griffin, Kurt J.
Hagopian, William
Haller, Michael J.
Hendrieckx, Christel
Hendriks, Emile
Holt, Richard I. G.
Hughes, Lucille
Ismail, Heba M.
Jacobsen, Laura M.
Johnson, Suzanne B.
Kolb, Leslie E.
Kordonouri, Olga
Lange, Karin
Lash, Robert W.
Lernmark, Ake
Libman, Ingrid
Lundgren, Markus
Maahs, David M.
Marcovecchio, M. Loredana
Mathieu, Chantal
Miller, Kellee M.
O'Donnell, Holly K.
Oron, Tal
Patil, Shivajirao P.
Pop-Busui, Rodica
Rewers, Marian J.
Rich, Stephen S.
DIABETOLOGIA, 2024, 67 (09) : 1731 - 1759
[2] Considerations for more actionable consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes
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[3] Consensus Guidance for Monitoring Individuals With Islet Autoantibody-Positive Pre-Stage 3 Type 1 Diabetes ( vol 47, pg 1276, 2024)
Phillip, Moshe
Achenbach, Peter
Addala, Ananta
Albanese-O'Neill, Anastasia
Battelino, Tadej
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Besser, Rachel E. J.
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Colhoun, Helen M.
Couper, Jennifer J.
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Frohnert, Brigitte I.
Gabbay, Robert A.
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Griffin, Kurt J.
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