EWSR1: the promiscuous king of mesenchymal neoplasia

被引：0

作者：

Towery, Emily Anne ^{[1
]}

Papke, David James ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

来源：

JOURNAL OF CLINICAL PATHOLOGY | 2024年 / 77卷 / 11期

关键词：

Pathology; Surgical; Sarcoma; Soft Tissue Neoplasms; CLEAR-CELL-SARCOMA; GENE FUSION; GASTROINTESTINAL-TRACT; CHIMERIC TRANSCRIPTS; FIBROUS HISTIOCYTOMA; MOLECULAR ANALYSIS; EWINGS-SARCOMA; YOUNG-ADULTS; TUMOR; TRANSLOCATION;

D O I：

10.1136/jcp-2023-208867

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

EWSR1 is the most commonly rearranged gene in mesenchymal neoplasia, and its myriad chimeric oncoproteins drive widely disparate neoplasms. Here, we survey selected EWSR1 rearrangements, including well-described EWSR1 fusions with CREB family members, ATF1 and CREB1, as well as fusions in emerging entities such as mesenchymal neoplasms with EWSR1::PATZ1 and EWSR1::NFATC2 fusions. We also discuss recent data demonstrating the imperfect specificity of EWSR1::WT1 and, possibly, EWSR1::FLI1 fusions.

引用

页码：721 / 725

页数：5

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