Nickel-Catalyzed Secondary Benzylic C-O Bond Borylation

被引：1

作者：

Li, Pengfei ^{[1
]}

Zhang, Chenyan ^{[1
]}

Wang, Jiaqi ^{[1
]}

Zhang, Lei ^{[1
]}

机构：

[1] Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 37期

基金：

中国国家自然科学基金;

关键词：

ARYL ETHERS; CARBON-OXYGEN; 2-PYRIDYL ETHERS; CROSS-COUPLINGS; METHYL ETHERS; ELECTROPHILES; ACTIVATION; REACTIVITY; CLEAVAGE;

D O I：

10.1021/acs.orglett.4c02920

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A remote steric hindrance ligand (m-Bu- t)(2)C6H3PCy2 (L1) was synthesized to promote Ni-catalyzed C-O bond activation. The reaction achieved high yields for secondary benzylic C(sp(3))-O borylation in non-pi-extended systems under mild conditions. Mechanistic studies indicate that the nickel complex containing 1 equiv of L1 serves as the active catalyst, while increased loading of L1 gives the inactive bisligated Ni species. Acetanilide is crucial for the cross-coupling reaction, which facilitates generation of the monoligated nickel species.

引用

页码：7932 / 7937

页数：6

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