Biology-guided radiotherapy in metastatic prostate cancer: time to push the envelope?

被引：1

作者：

Lancia, Andrea ^{[1
]}

Ingrosso, Gianluca ^{[2
]}

Detti, Beatrice ^{[3
]}

Festa, Eleonora ^{[2
]}

Bonzano, Elisabetta ^{[1
]}

Linguanti, Flavia ^{[4
]}

Camilli, Federico ^{[2
]}

Bertini, Niccolo ^{[5
]}

La Mattina, Salvatore ^{[1
]}

Orsatti, Carolina ^{[5
]}

Francolini, Giulio ^{[5
]}

Abenavoli, Elisabetta Maria ^{[6
]}

Livi, Lorenzo ^{[5
]}

Aristei, Cynthia ^{[2
]}

de Jong, Dorine ^{[7
]}

Al Feghali, Karine A. ^{[7
]}

Siva, Shankar ^{[8
,9
]}

Becherini, Carlotta ^{[5
]}

机构：

[1] Ist Ricovero & Cura Carattere Sci IRCCS, San Matteo Hosp Fdn, Dept Radiat Oncol, Pavia, Italy

[2] Univ Perugia, Radiat Oncol Sect, Perugia, Italy

[3] Usl Ctr Toscana, Radiotherapy Unit Prato, Presidio Villa Fior, Prato, Italy

[4] Osped San Donato, Nucl Med Dept, Arezzo, Italy

[5] Azienda Osped Univ Careggi, Oncol Dept, Radiat Oncol Unit, Florence, Italy

[6] Careggi Univ Hosp, Nucl Med Div, Florence, Italy

[7] RefleXion Med Inc, Med Affairs, Hayward, CA 94545 USA

[8] Sir Peter MacCallum Canc Ctr, Dept Radiat Oncol, Melbourne, Vic, Australia

[9] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia

来源：

FRONTIERS IN ONCOLOGY | 2024年 / 14卷

关键词：

radiotherapy; prostate cancer; PET/CT; biology-guided radiotherapy; metastases; BIOCHEMICAL RECURRENCE; RADICAL PROSTATECTOMY; ABLATIVE RADIATION; BODY RADIOTHERAPY; LYMPH-NODES; THERAPY; DISEASE; PET/CT; IMMUNOTHERAPY; STRATEGIES;

D O I：

10.3389/fonc.2024.1455428

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The therapeutic landscape of metastatic prostate cancer has undergone a profound revolution in recent years. In addition to the introduction of novel molecules in the clinics, the field has witnessed a tremendous development of functional imaging modalities adding new biological insights which can ultimately inform tailored treatment strategies, including local therapies. The evolution and rise of Stereotactic Body Radiotherapy (SBRT) have been particularly notable in patients with oligometastatic disease, where it has been demonstrated to be a safe and effective treatment strategy yielding favorable results in terms of disease control and improved oncological outcomes. The possibility of debulking all sites of disease, matched with the ambition of potentially extending this treatment paradigm to polymetastatic patients in the not-too-distant future, makes Biology-guided Radiotherapy (BgRT) an attractive paradigm which can be used in conjunction with systemic therapy in the management of patients with metastatic prostate cancer.

引用

页数：10

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