Enhancing Pathogen Detection in Implant-Related Infections through Chemical Antibiofilm Strategies: A Comprehensive Review

被引:0
|
作者
Giarritiello, Fabiana [1 ]
Romano, Carlo Luca [2 ]
Lob, Guenter [3 ]
Benevenia, Joseph [4 ]
Tsuchiya, Hiroyuki [5 ]
Zappia, Emanuele [1 ]
Drago, Lorenzo [6 ,7 ]
机构
[1] Univ Molise, Dept Med & Hlth Sci V Tiberio, I-86100 Campobasso, Italy
[2] Romano Inst, Tirana 1001, Albania
[3] Deutsch Gesell Orthopad & Unfallchirurg DGOU, Sect Injury Prevent, D-10117 Berlin, Germany
[4] Rutgers New Jersey Med Sch, Dept Orthopaed, Newark, NJ 07103 USA
[5] Kanazawa Univ, Grad Sch Med Sci, Dept Orthopaed Surg, Kanazawa 9208641, Japan
[6] Univ Milan, Dept Biomed Sci Hlth, Clin Microbiol & Microbiome Lab, I-20133 Milan, Italy
[7] IRCCS Multimed Hosp, UOC Lab Clin Med Specialized Areas, I-20138 Milan, Italy
来源
ANTIBIOTICS-BASEL | 2024年 / 13卷 / 07期
关键词
infections; biofilm; diagnostic techniques; chemical agents; implant-related infections (IRIs); orthopedic and cardiovascular devices; revision surgery; PERIPROSTHETIC JOINT INFECTION; POLYMERASE-CHAIN-REACTION; TOTAL HIP-ARTHROPLASTY; RIBOSOMAL-RNA GENE; BACTERIAL BIOFILM; KNEE ARTHROPLASTY; IN-VITRO; SONICATION FLUID; 2-STAGE EXCHANGE; BLOOD CULTURE;
D O I
10.3390/antibiotics13070678
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Implant-related infections (IRIs) represent a significant challenge to modern surgery. The occurrence of these infections is due to the ability of pathogens to aggregate and form biofilms, which presents a challenge to both the diagnosis and subsequent treatment of the infection. Biofilms provide pathogens with protection from the host immune response and antibiotics, making detection difficult and complicating both single-stage and two-stage revision procedures. This narrative review examines advanced chemical antibiofilm techniques with the aim of improving the detection and identification of pathogens in IRIs. The articles included in this review were selected from databases such as PubMed, Scopus, MDPI and SpringerLink, which focus on recent studies evaluating the efficacy and enhanced accuracy of microbiological sampling and culture following the use of chemical antibiofilm. Although promising results have been achieved with the successful application of some antibiofilm chemical pre-treatment methods, mainly in orthopedics and in cardiovascular surgery, further research is required to optimize and expand their routine use in the clinical setting. This is necessary to ensure their safety, efficacy and integration into diagnostic protocols. Future studies should focus on standardizing these techniques and evaluating their effectiveness in large-scale clinical trials. This review emphasizes the importance of interdisciplinary collaboration in developing reliable diagnostic tools and highlights the need for innovative approaches to improve outcomes for patients undergoing both single-stage and two-stage revision surgery for implant-related infections.
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页数:11
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