NIR laser-activated phthalocyanine loaded lipid nanoparticles targeting M2 macrophage for improved photoacoustic imaging-guided photothermal therapy

被引：1

作者：

Peng, Xingzhou ^{[1
]}

Wang, Junjie ^{[2
,3
,4
]}

Deng, Zihan ^{[5
]}

Wei, Jianshuang ^{[2
,3
]}

Xie, Changqiang ^{[1
]}

Wang, Yan ^{[1
]}

Han, Jianlei ^{[6
]}

Chen, Zhengyu ^{[1
]}

Du, Jianghai ^{[1
]}

Zhang, Zhihong ^{[1
,2
,3
]}

机构：

[1] Hainan Univ, Sch Biomed Engn, State Key Lab Digital Med Engn, Key Lab Biomed Engn Hainan Prov, Sanya 572025, Hainan, Peoples R China

[2] Huazhong Univ Sci & Technol, Britton Chance Ctr, Wuhan 430074, Hubei, Peoples R China

[3] Huazhong Univ Sci & Technol, MoE Key Lab Biomed Photon, Wuhan Natl Lab Optoelect, Wuhan 430074, Hubei, Peoples R China

[4] Hainan Med Univ, Affiliated Hosp 1, Engn Res Ctr Hainan Biosmart Mat & Biomed Devices, Key Lab Emergency & Trauma,Minist Educ,Key Lab Hai, Haikou 571199, Peoples R China

[5] Wuhan Univ, ZhongNan Hosp, Dept Thorac Surg, Wuhan 430074, Hubei, Peoples R China

[6] CAS Key Lab Nanosyst & Hierarch Fabricat, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China

来源：

MATERIALS TODAY BIO | 2024年 / 28卷

关键词：

Breast cancer; M2; macrophage; Ruthenium phthalocyanine; Photothermal therapy; Deep penetration; PHOTODYNAMIC THERAPY; PHOTOSENSITIZER; AGENT;

D O I：

10.1016/j.mtbio.2024.101209

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The development of novel phototheranostic agents with significant potential in bioimaging-guided therapy is highly desirable for precise tumor therapy. Herein, NIR laser-activated ruthenium phthalocyanine (PcRu) loaded sub-30 nm targeting lipid nanoparticles (alpha-PcRu-NPs) were fabricated for photoacoustic imaging (PAI)-guided photothermal therapy (PTT). Due to the formation of J-type aggregation of PcRu in the core of the nanostructure, the alpha-PcRu-NPs exhibited high stability, efficient NIR absorption, reduced singlet oxygen generation, high photothermal activity, and intense photoacoustic signal. With the M2 macrophage target peptide (M2pep) modification and small size of alpha-PcRu-NPs, in vivo evaluations reveal that alpha-PcRu-NPs can specifically target and deeply penetrate the tumor foci. Under a high contrast PAI guidance with alpha-PcRu-NPs (744 nm, 0.35 mu W), it also realizes superior photothermal therapy (PTT) for breast cancer under 670 nm laser irradiation (0.5 W/cm(2)). The prominent therapeutic efficacy of alpha-PcRu-NP-based PTT not only directly kills tumor cells, but also enhances the immune response by promoting dendritic cell maturation and increasing cytotoxic T cell infiltration. Thus, this work broadens the applications of phthalocyanine derivatives as phototheranostics in the PAI-guided PTT field.

引用

页数：11