The genetic association between bipolar disorder and dementia: a qualitative review

被引：0
|
作者：
Hirakawa, Hirofumi [1 ]
Terao, Takeshi [1 ]
机构：
[1] Oita Univ, Fac Med, Dept Neuropsychiat, Yufu, Oita, Japan
来源：
FRONTIERS IN PSYCHIATRY | 2024年 / 15卷
关键词：
bipolar disorder; dementia; gene; single nucleotide polymorphisms; genome-wide association study; GENOME-WIDE ASSOCIATION; METHIONINE-SULFOXIDE-REDUCTASE; ALZHEIMERS-DISEASE; I DISORDER; COGNITIVE IMPAIRMENT; SUSCEPTIBILITY LOCI; EUTHYMIC STATES; RISK LOCI; CACNA1C; METAANALYSIS;
D O I：
10.3389/fpsyt.2024.1414776
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Bipolar disorder is a chronic disorder characterized by fluctuations in mood state and energy and recurrent episodes of mania/hypomania and depression. Bipolar disorder may be regarded as a neuro-progressive disorder in which repeated mood episodes may lead to cognitive decline and dementia development. In the current review, we employed genome-wide association studies to comprehensively investigate the genetic variants associated with bipolar disorder and dementia. Thirty-nine published manuscripts were identified: 20 on bipolar disorder and 19 on dementia. The results showed that the genes CACNA1C, GABBR2, SCN2A, CTSH, MSRA, and SH3PXD2A were overlapping between patients with bipolar disorder and dementia. In conclusion, the genes CACNA1C, GABBR2, SCN2A, CTSH, MSRA, and SH3PXD2A may be associated with the neuro-progression of bipolar disorder to dementia. Further genetic studies are needed to comprehensively clarify the role of genes in cognitive decline and the development of dementia in patients with bipolar disorder.
引用
收藏
页数：9
相关论文
共 50 条
  • [1] Assessment of Genetic Association Between Parkinson Disease and Bipolar Disorder
    Bandres-Ciga, Sara
    Blauwendraat, Cornelis
    Singleton, Andrew B.
    JAMA NEUROLOGY, 2020, 77 (08) : 1034 - 1035
  • [2] Bipolar Disorder and Frontotemporal Dementia: An Intriguing Association
    Papazacharias, Apostolos
    Lozupone, Madia
    Barulli, Maria Rosaria
    Capozzo, Rosa
    Imbimbo, Bruno P.
    Veneziani, Federica
    De Blasi, Roberto
    Nardini, Marcello
    Seripa, Davide
    Panza, Francesco
    Logroscino, Giancarlo
    JOURNAL OF ALZHEIMERS DISEASE, 2017, 55 (03) : 973 - 979
  • [3] Association Between Groundwater Lithium and the Diagnosis of Bipolar Disorder and Dementia in the United States
    Parker, William F.
    Gorges, Rebecca J.
    Gao, Y. Nina
    Zhang, Yudong
    Hur, Kwan
    Gibbons, Robert D.
    JAMA PSYCHIATRY, 2018, 75 (07) : 751 - 754
  • [4] Association between CRP genetic diversity and bipolar disorder comorbid complications
    Wahid Boukouaci
    José Oliveira
    Bruno Etain
    Meriem Bennabi
    Christina Mariaselvam
    Nora Hamdani
    Céline Manier
    Djaouida Bengoufa
    Frank Bellivier
    Chantal Henry
    Jean-Pierre Kahn
    Dominique Charron
    Rajagopal Krishnamoorthy
    Marion Leboyer
    Ryad Tamouza
    International Journal of Bipolar Disorders, 6
  • [5] Association between CRP genetic diversity and bipolar disorder comorbid complications
    Boukouaci, Wahid
    Oliveira, Jose
    Etain, Bruno
    Bennabi, Meriem
    Mariaselvam, Christina
    Hamdani, Nora
    Manier, Celine
    Bengoufa, Djaouida
    Bellivier, Frank
    Henry, Chantal
    Kahn, Jean-Pierre
    Charron, Dominique
    Krishnamoorthy, Rajagopal
    Leboyer, Marion
    Tamouza, Ryad
    INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS, 2018, 6
  • [6] Genetic differences between bipolar disorder subtypes: A systematic review focused in bipolar disorder type II
    Almeida, Hugo Sergio
    Mitjans, Marina
    Arias, Barbara
    Vieta, Eduard
    Rios, Jose
    Benabarre, Antonio
    NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2020, 118 : 623 - 630
  • [7] Bipolar disorder and frontotemporal dementia: A systematic review
    Meller, Marina Roman
    Patel, Swara
    Duarte, Dante
    Kapczinski, Flavio
    Cardoso, Taiane de Azevedo
    ACTA PSYCHIATRICA SCANDINAVICA, 2021, 144 (05) : 433 - 447
  • [8] Bipolar disorder and frontotemporal dementia: A systematic review
    Patel, Swara
    Meller, Marina Roman
    Kapczinski, Flavio
    Cardoso, Taiane de Azevedo
    BIPOLAR DISORDERS, 2021, 23 : 77 - 77
  • [9] A review on shared clinical and molecular mechanisms between bipolar disorder and frontotemporal dementia
    Nascimento, Camila
    Nunes, Paula Villela
    Rodriguez, Roberta Diehl
    Takada, Leonel
    Suemoto, Claudia Kimie
    Grinberg, Lea Tenenholz
    Nitrini, Ricardo
    Lafer, Beny
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2019, 93 : 269 - 283
  • [10] Differential diagnosis between frontotemporal dementia and bipolar disorder, review and case report
    Garcia Moreno, M.
    De Cos Milas, A.
    Beatobe Carreno, L.
    Del Sol Calderon, P.
    Izquierdo de la Puente, A.
    EUROPEAN PSYCHIATRY, 2024, 67 : S639 - S639
12345