An endogenous oxygen self-supplied nanoplatform with GSH-depleted and NIR-II triggered electron-hole separation for enhanced photocatalytic anti-tumor therapy

被引：0

作者：

Huang, Yao ^{[1
,2
]}

Wei, Hanlin ^{[2
]}

Feng, Hui ^{[4
]}

Tian, Fengyu ^{[2
]}

Zheng, Qi ^{[3
]}

Deng, Zhiming ^{[2
]}

机构：

[1] Xiangnan Univ, Sch Phys & Elect Elect Engn, Chenzhou 423000, Peoples R China

[2] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China

[3] Hunan Univ, Sch Phys & Elect, Key Lab Micronano Optoelect Devices, Minist Educ, Changsha, Peoples R China

[4] Changsha Environm Protect Coll, Changsha 410082, Hunan, Peoples R China

来源：

PHYSICAL CHEMISTRY CHEMICAL PHYSICS | 2024年 / 26卷 / 35期

基金：

中国博士后科学基金;

关键词：

D O I：

10.1039/d4cp02554g

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The use of artificial enzymes and light energy in photocatalytic therapy, a developing drug-free therapeutic approach, can treat malignant tumors in vivo. However, the relatively deficient oxygen concentration in the tumor microenvironment (TME) restrains their further tumor treatment capability. Herein, a novel nanoplatform with Cu7S4@Au nanocatalyst coated by MnO2 was successfully designed. After 1064 nm light irradiation, the designed nanocatalyst can promote the separation of light generated electron-hole pairs, resulting in ROS generation and tumor cell apoptosis. The MnO2 shelled nanoplatform can function as a TME-responsive oxygen self-supplied producer to improve photocatalyst treatment and GSH depletion. In summary, the designed novel nanoplatform shows efficient inhibition of tumor growth via GSH depletion and synergistic photocatalytic therapy, which is of great significance for improving the clinical tumor treatment effect. The use of artificial enzymes and light energy in photocatalytic therapy, a developing drug-free therapeutic approach, can treat malignant tumors in vivo.

引用

页码：23386 / 23392

页数：7