89Zr PET imaging guided validation of the medicinal potentiality of UiO-66 based nano drug delivery system

被引：1
|
作者：
Tan, Fuyuan [1 ]
Li, Wenliang [1 ]
Qiu, Long [1 ]
Lyu, Jie [1 ]
Peng, Haiyue [1 ]
Ding, Wenbing [1 ]
Liao, Jiali [1 ]
Yang, Yuanyou [1 ]
Liu, Ning [1 ]
Li, Feize [1 ]
机构：
[1] Sichuan Univ, Inst Nucl Sci & Technol, Key Lab Radiat Phys & Technol, Minist Educ, 29 Wang Jiang Rd, Chengdu 610064, Sichuan, Peoples R China
来源：
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2025年 / 334卷 / 01期
基金：
中国国家自然科学基金; 中央高校基本科研业务费专项资金资助;
关键词：
Chemotherapy; Nano drug delivery system; Metal-organic frameworks; PET-CT; METAL-ORGANIC FRAMEWORKS; NANOPARTICLES; NANOCOMPOSITE; DESIGN;
D O I：
10.1007/s10967-024-09723-z
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
In this work, positron nuclide Zr-89 was introduced to verify the medical feasibility of UiO-66 as a medical nanodrug carrier via positron emission tomography-computed tomography (PET-CT) imaging. A radiopharmaceutical nanodrug, DOX@Zr-89-UiO-66-PEG-FA, was well constructed through subsequent doxorubicin (DOX) encapsulation and surface PEGylation of UiO-66 nanocarrier radiolabeled with Zr-89. Subsequently, tumoricidal effect of DOX@Zr-89-UiO-66-PEG-FA in murine breast cancer (4T1) models had been evaluated. DOX@Zr-89-UiO-66-PEG-FA has acceptable stability, excellent cargo loading rate (79.28%), pH-stimulated response property and high cancer cell binding affinity. As a result, PET-CT guided anticancer investigations reveal that DOX@Zr-89-UiO-66-PEG-FA can well suppress tumor growth with satisfactory biosafety. [GRAPHICS] .
引用
收藏
页码：239 / 250
页数：12
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