Synthesis of novel star-shaped molecules based on a pentaerythritol core linked to different heterocyclic systems

被引:2
|
作者
Diab, Hadeer M. [1 ]
Abdelhamid, Ismail A. [1 ]
Salem, Mostafa E. [2 ]
Ragab, Islam [3 ]
Zaki, Magdi E. A. [2 ]
Abdelmoniem, Amr M. [1 ]
Elwahy, Ahmed H. M. [1 ]
机构
[1] Cairo Univ, Fac Sci, Dept Chem, Giza 12613, Egypt
[2] Imam Mohammad Ibn Saud Islamic Univ IMSIU, Coll Sci, POB 90950, Riyadh 11623, Saudi Arabia
[3] Qassim Univ, Coll Sci, Dept Chem, Buraydah 51452, Saudi Arabia
关键词
Pentaerythrityl tetrabenzaldehyde; Biginelli and Hantzsch reactions; Star-Shaped molecules with a pentaerythritol core; Thiazoles; Hexahydroacridinediones; decahydropyrimido; 4,5-b]quinolones; Tetrahydro[1,2,4]triazolo[5,1-b]quinazoline; BIOLOGICAL EVALUATION; THIAZOLE DERIVATIVES; OPTOELECTRONIC PROPERTIES; VERSATILE PRECURSORS; DOCKING; DESIGN; EFFICIENT;
D O I
10.1016/j.rechem.2024.101726
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Synthesis of analogs of known active compounds is the most often employed strategy for producing important compounds. The Hantzsch reaction was employed to create new star-shaped compounds with a pentaerythritol core connected to thiazoles, hexahydroacridinediones, decahydropyrimido[4,5-b]quinolones, b ]quinolones, and tetrahydro [1,2,4]triazolo[5,1-b]quinazoline b ]quinazoline in this study. The flexible precursor was 4 '-((2,2-bis((4-formylphenoxy)methyl) '-((2,2-bis((4-formylphenoxy)methyl) propane-1,3-diyl)bis(oxy))dibenzaldehyde. Under milder reaction conditions, the target compounds were produced with high yields as well as shorter reaction times. The structures of the new compounds were established using elemental analysis and spectral data.
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页数:12
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