Study on the Synergistic Effects of Cu and Sr on Biodegradable Zn Alloys

Bone defect repair and postoperative infections are among the most challenging issues faced by orthopedic surgeons. Thus, the antibacterial agent Cu and the osteogenic promoter Sr have been widely incorporated into biodegradable alloys separately. However, to the best of our knowledge, the synergistic effects of Cu and Sr on zinc alloys have not been investigated. Therefore, we have developed a series of novel Zn-4Cu-xSr (x = 0.05, 0.1, and 0.3 wt %) alloys. Our results showed that the addition of Cu and Sr significantly increased the strength of pure zinc while maintaining a certain level of ductility. Plastic deformation further enhanced the strength and ductility of the alloys. The tensile strength of HR Zn-4Cu-xSr alloys remains between 233.34 +/- 1.31 MPa and 235.81 +/- 3.0 MPa, with elongation values ranging from 45.7 +/- 1.56% to 49.6 +/- 6.22%. The HE Zn-4Cu-0.05Sr alloy exhibits a high elongation of 95.05 +/- 11.1%. Furthermore, the HE Zn-4Cu-0.1Sr alloy demonstrates the best overall mechanical performance with ultimate tensile strength (sigma(uts) ), yield strength (sigma(ys) ), and elongation (epsilon) values of 252.73 +/- 0.12 MPa, 181.0 +/- 0.79 MPa, and 42.8 +/- 1.13%, respectively. The corrosion rate of HE Zn-4Cu-xSr alloys increases with an increase in Sr content. All samples exhibit satisfactory cytocompatibility with the cells displaying a healthy spindle-like morphology. In vitro antibacterial tests show that the HE Zn-4Cu-xSr alloys exhibit significant antibacterial effects against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), with the antibacterial properties strengthening as the Sr content increases. Therefore, this study demonstrates the tremendous potential application of Zn-4Cu-xSr alloys in biodegradable zinc alloys for bone fracture fixation and repair.