Acanthamoeba, are ubiquitous eukaryotic microorganisms, that play a pivotal role in recognizing and engulfing various microbes during predation, offering insights into microbial dynamics and immune responses. An intriguing observation lies in the apparent preference of Acanthamoeba for Gram-negative over Gram-positive bacteria, suggesting potential differences in the recognition and response mechanisms to bacterial prey. Here, we comprehensively review pattern recognition receptors (PRRs) and microbe associated molecular patterns (MAMPs) that influence Acanthamoeba interactions with bacteria. We analyze the molecular mechanisms underlying these interactions, and the key finding of this review is that Acanthamoeba exhibits an affinity for bacterial cell surface appendages that are decorated with carbohydrates. Notably, this parallels warm-blooded immune cells, underscoring a conserved evolutionary strategy in microbial recognition. This review aims to serve as a foundation for exploring PRRs and MAMPs. These insights enhance our understanding of ecological and evolutionary dynamics in microbial interactions and shed light on fundamental principles governing immune responses. Leveraging Acanthamoeba as a model organism, provides a bridge between ecological interactions and immunology, offering valuable perspectives for future research.
机构:
Harvard Med Sch, Massachusetts Gen Hosp, Vincent Ctr Reprod Biol, Boston, MA USAHarvard Med Sch, Massachusetts Gen Hosp, Vincent Ctr Reprod Biol, Boston, MA USA
Foessleitner, P.
Demidkina, B. Cooley
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Vincent Ctr Reprod Biol, Boston, MA USAHarvard Med Sch, Massachusetts Gen Hosp, Vincent Ctr Reprod Biol, Boston, MA USA
Demidkina, B. Cooley
El-Arar, W.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Vincent Ctr Reprod Biol, Boston, MA USAHarvard Med Sch, Massachusetts Gen Hosp, Vincent Ctr Reprod Biol, Boston, MA USA
El-Arar, W.
Goldenberg, M.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Vincent Ctr Reprod Biol, Boston, MA USAHarvard Med Sch, Massachusetts Gen Hosp, Vincent Ctr Reprod Biol, Boston, MA USA
Goldenberg, M.
Murthy, M.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Vincent Ctr Reprod Biol, Boston, MA USAHarvard Med Sch, Massachusetts Gen Hosp, Vincent Ctr Reprod Biol, Boston, MA USA
Murthy, M.
Bergerat-Thompson, A.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Vincent Ctr Reprod Biol, Boston, MA USAHarvard Med Sch, Massachusetts Gen Hosp, Vincent Ctr Reprod Biol, Boston, MA USA
Bergerat-Thompson, A.
Kwon, D.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, Ragon Inst MGH MIT & Harvard, Massachusetts Gen Hosp, Boston, MA USAHarvard Med Sch, Massachusetts Gen Hosp, Vincent Ctr Reprod Biol, Boston, MA USA
Kwon, D.
Mitchell, C.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, Massachusetts Gen Hosp, Vincent Ctr Reprod Biol, Boston, MA USAHarvard Med Sch, Massachusetts Gen Hosp, Vincent Ctr Reprod Biol, Boston, MA USA
机构:
University of California,Division of Infectious Diseases, Department of MedicineUniversity of California,Division of Infectious Diseases, Department of Medicine
Natasha Spottiswoode
Alexandra Tsitsiklis
论文数: 0引用数: 0
h-index: 0
机构:
University of California,Division of Infectious Diseases, Department of MedicineUniversity of California,Division of Infectious Diseases, Department of Medicine
Alexandra Tsitsiklis
Victoria T. Chu
论文数: 0引用数: 0
h-index: 0
机构:
University of California,Department of PediatricsUniversity of California,Division of Infectious Diseases, Department of Medicine
Victoria T. Chu
Hoang Van Phan
论文数: 0引用数: 0
h-index: 0
机构:
Chan Zuckerberg Biohub San Francisco,Division of Pulmonary, Department of Medicine, Critical Care, Allergy and Sleep MedicineUniversity of California,Division of Infectious Diseases, Department of Medicine
Hoang Van Phan
Catherine DeVoe
论文数: 0引用数: 0
h-index: 0
机构:
University of California,Division of Infectious Diseases, Department of MedicineUniversity of California,Division of Infectious Diseases, Department of Medicine
Catherine DeVoe
Christina Love
论文数: 0引用数: 0
h-index: 0
机构:
University of California,Division of Infectious Diseases, Department of MedicineUniversity of California,Division of Infectious Diseases, Department of Medicine
Christina Love
Rajani Ghale
论文数: 0引用数: 0
h-index: 0
机构:
University of California,Division of Infectious Diseases, Department of MedicineUniversity of California,Division of Infectious Diseases, Department of Medicine
Rajani Ghale
Joshua Bloomstein
论文数: 0引用数: 0
h-index: 0
机构:
University of California,Division of Infectious Diseases, Department of MedicineUniversity of California,Division of Infectious Diseases, Department of Medicine
Joshua Bloomstein
Beth Shoshana Zha
论文数: 0引用数: 0
h-index: 0
机构:
University of California,Department of MedicineUniversity of California,Division of Infectious Diseases, Department of Medicine
Beth Shoshana Zha
Cole P. Maguire
论文数: 0引用数: 0
h-index: 0
机构:
University of Washington,Department of PediatricsUniversity of California,Division of Infectious Diseases, Department of Medicine
Cole P. Maguire
Abigail Glascock
论文数: 0引用数: 0
h-index: 0
机构:
University of California,Department of MedicineUniversity of California,Division of Infectious Diseases, Department of Medicine
Abigail Glascock
Aartik Sarma
论文数: 0引用数: 0
h-index: 0
机构:
University of Texas,Department of Biochemistry and BiophysicsUniversity of California,Division of Infectious Diseases, Department of Medicine
Aartik Sarma
Peter M. Mourani
论文数: 0引用数: 0
h-index: 0
机构:
Chan Zuckerberg Biohub San Francisco,Division of Pulmonary, Department of Medicine, Critical Care, Allergy and Sleep MedicineUniversity of California,Division of Infectious Diseases, Department of Medicine
Peter M. Mourani
Katrina L. Kalantar
论文数: 0引用数: 0
h-index: 0
机构:
University of California,Department of MedicineUniversity of California,Division of Infectious Diseases, Department of Medicine
Katrina L. Kalantar
Angela Detweiler
论文数: 0引用数: 0
h-index: 0
机构:
Arkansas Children’s,UCSF CoLabsUniversity of California,Division of Infectious Diseases, Department of Medicine
Angela Detweiler
Norma Neff
论文数: 0引用数: 0
h-index: 0
机构:
Chan Zuckerberg Initiative,Lung Biology CenterUniversity of California,Division of Infectious Diseases, Department of Medicine
Norma Neff
Sidney C. Haller
论文数: 0引用数: 0
h-index: 0
机构:
Chan Zuckerberg Biohub San Francisco,Division of Pulmonary, Department of Medicine, Critical Care, Allergy and Sleep MedicineUniversity of California,Division of Infectious Diseases, Department of Medicine
Sidney C. Haller
Joseph L. DeRisi
论文数: 0引用数: 0
h-index: 0
机构:
Chan Zuckerberg Biohub San Francisco,Division of Pulmonary, Department of Medicine, Critical Care, Allergy and Sleep MedicineUniversity of California,Division of Infectious Diseases, Department of Medicine
Joseph L. DeRisi
David J. Erle
论文数: 0引用数: 0
h-index: 0
机构:
University of California,Department of MedicineUniversity of California,Division of Infectious Diseases, Department of Medicine
David J. Erle
Carolyn M. Hendrickson
论文数: 0引用数: 0
h-index: 0
机构:
Chan Zuckerberg Biohub San Francisco,Division of Pulmonary, Department of Medicine, Critical Care, Allergy and Sleep MedicineUniversity of California,Division of Infectious Diseases, Department of Medicine
Carolyn M. Hendrickson
Kirsten N. Kangelaris
论文数: 0引用数: 0
h-index: 0
机构:
University of California,Department of MedicineUniversity of California,Division of Infectious Diseases, Department of Medicine
Kirsten N. Kangelaris
Matthew F. Krummel
论文数: 0引用数: 0
h-index: 0
机构:
University of California,Department of MedicineUniversity of California,Division of Infectious Diseases, Department of Medicine
Matthew F. Krummel
Michael A. Matthay
论文数: 0引用数: 0
h-index: 0
机构:
University of California,Department of PathologyUniversity of California,Division of Infectious Diseases, Department of Medicine
Michael A. Matthay
Prescott G. Woodruff
论文数: 0引用数: 0
h-index: 0
机构:
University of California,Cardiovascular Research InstituteUniversity of California,Division of Infectious Diseases, Department of Medicine
Prescott G. Woodruff
Carolyn S. Calfee
论文数: 0引用数: 0
h-index: 0
机构:
University of California,Department of MedicineUniversity of California,Division of Infectious Diseases, Department of Medicine
Carolyn S. Calfee
Charles R. Langelier
论文数: 0引用数: 0
h-index: 0
机构:
University of California,Department of AnesthesiaUniversity of California,Division of Infectious Diseases, Department of Medicine