Unravelling mechanisms of bacterial recognition by Acanthamoeba: insights into microbial ecology and immune responses

被引:0
|
作者
Nasher, Fauzy [1 ]
Wren, Brendan W. [1 ]
机构
[1] London Sch Hyg & Trop Med, Dept Infect Biol, London, England
基金
英国生物技术与生命科学研究理事会;
关键词
Acanthamoeba; pattern recognition receptors; microbe-associated molecular patterns; phagocytosis; immune recognition; flagellin; lipopolysaccharides; lipoteichoic acid; LISTERIA-MONOCYTOGENES; DICTYOSTELIUM-DISCOIDEUM; BINDING LECTIN; PROTEIN; FLAGELLA; LIPOPOLYSACCHARIDE; IDENTIFICATION; CASTELLANII; PHYSIOLOGY; EVOLUTION;
D O I
10.3389/fmicb.2024.1405133
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Acanthamoeba, are ubiquitous eukaryotic microorganisms, that play a pivotal role in recognizing and engulfing various microbes during predation, offering insights into microbial dynamics and immune responses. An intriguing observation lies in the apparent preference of Acanthamoeba for Gram-negative over Gram-positive bacteria, suggesting potential differences in the recognition and response mechanisms to bacterial prey. Here, we comprehensively review pattern recognition receptors (PRRs) and microbe associated molecular patterns (MAMPs) that influence Acanthamoeba interactions with bacteria. We analyze the molecular mechanisms underlying these interactions, and the key finding of this review is that Acanthamoeba exhibits an affinity for bacterial cell surface appendages that are decorated with carbohydrates. Notably, this parallels warm-blooded immune cells, underscoring a conserved evolutionary strategy in microbial recognition. This review aims to serve as a foundation for exploring PRRs and MAMPs. These insights enhance our understanding of ecological and evolutionary dynamics in microbial interactions and shed light on fundamental principles governing immune responses. Leveraging Acanthamoeba as a model organism, provides a bridge between ecological interactions and immunology, offering valuable perspectives for future research.
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页数:10
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