An electron donor-acceptor complex-initiated C-H trifluoromethylation and perfluoroalkylation of enamides and quinoxalinones

被引：1

作者：

Song, Yaqi ^{[1
]}

Sun, Tian-Yu ^{[3
]}

Xia, Xiao-Feng ^{[1
,2
]}

Wang, Dawei ^{[1
]}

机构：

[1] Jiangnan Univ, Sch Chem & Mat Engn, Key Lab Synthet & Biol Colloids, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China

[2] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China

[3] Peking Univ, Key Lab Computat Chem & Drug Design, State Key Lab Chem Oncogenom, Shenzhen Key Lab Chem Genom,Sch Chem Biol & Biotec, Shenzhen 518055, Guangdong, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 41期

基金：

美国国家科学基金会;

关键词：

CATALYZED TRIFLUOROMETHYLATION; METAL; ALKENES; ALKYNES; OXIDANT;

D O I：

10.1039/d4ob01228c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Facilitated by an electron donor-acceptor (EDA) complex, an efficient beta-trifluoromethylation and perfluoroalkylation of enamides with Togni reagent or perfluoroalkyl iodides is presented under transition-metal-free, photocatalyst-free and mild reaction conditions. Notably, using this photocatalyst-free strategy, direct trifluoromethylation and perfluoroalkylation of quinoxalin-2(1H)-one derivatives was also achieved via a photoactive electron donor-acceptor complex. An electron donor-acceptor complex-initiated C-H trifluoromethylation and perfluoroalkylation of enamides and quinoxalinones has been realized.

引用

页码：8317 / 8322

页数：6

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