Not too much, not too little-just the right amount: the story of YAP in the podocyte

被引：0
|
作者：
McEvoy, Caitriona M. [1 ,2 ]
Yuen, Darren A. [3 ,4 ,5 ,6 ]
机构：
[1] Tallaght Univ Hosp, Trinity Hlth Kidney Ctr, Dublin, Ireland
[2] Trinity Coll Dublin, Trinity Kidney Ctr, Dublin, Ireland
[3] Univ Toronto, St Michaels Hosp, Keenan Res Ctr Biomed Sci, Unity Hlth Toronto,Div Nephrol, Toronto, ON, Canada
[4] Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Unity Hlth Toronto, Toronto, ON, Canada
[5] Univ Toronto, Dept Med, Toronto, ON, Canada
[6] St Michaels Hosp, Univ Toronto, Dept Med, Unity Hlth Toronto, 209 Victoria St,5th Floor,Room 509, Toronto, ON M5B 1T8, Canada
来源：
KIDNEY INTERNATIONAL | 2024年 / 105卷 / 06期
关键词：
D O I：
10.1016/j.kint.2024.02.016
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Chen et al. identify dysregulation of the transcriptional activator Yes- associated protein in the podocytes of diabetic mouse and human kidneys. Podocyte Yes-associated protein deficiency fi ciency led to downregulation of the key transcription factor Wilms' ' tumor 1, and worsened podocyte injury in a mouse model of diabetic kidney injury. Yes-associated protein may therefore play a critical role in diabetic podocyte injury via regulation of Wilms' ' tumor 1 expression.
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页码：1157 / 1159
页数：3
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