Photocatalytic Decarboxylative Allylation of α-Amino Acids and Peptides under Metal-Free Conditions

被引：2

作者：

Zhang, Yinlei ^{[1
]}

Lu, Yanyu ^{[1
]}

Ju, Chengyang ^{[1
]}

Zhang, Zhenguo ^{[2
,3
]}

Wang, Dongping ^{[2
]}

Wang, Shirui ^{[3
]}

Xie, Peizhong ^{[1
]}

Loh, Teck-Peng ^{[2
,3
]}

机构：

[1] Nanjing Tech Univ, Sch Chem & Mol Engn, Nanjing 211816, Peoples R China

[2] Henan Univ Technol, Coll Adv Interdisciplinary Sci & Technol, Zhengzhou 450001, Peoples R China

[3] Nanyang Technol Univ, Div Chem & Biol Chem, Sch Phys & Math Sci, Singapore 637371, Singapore

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 38期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1021/acs.orglett.4c03038

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We developed an organophotoredox catalytic system to facilitate the decarboxylative allylation coupling process concerning alpha-amino acids and related C-terminal carboxylate peptides using Morita-Baylis-Hillman adducts as allylic precursors. This metal-free method operates under mild conditions and is compatible with various amino acids. The versatility of this protocol, particularly in chemical biology research, has been preliminarily demonstrated through the ligation of bioactive peptide chains.

引用

页码：8121 / 8127

页数：7

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