The Effects of Mucolytic Agents N-Acetylcysteine and Erdosteine on Hemostasis in Humans
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Oktar, S.
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Univ Hlth Sci, Beyhekim Training & Res Hosp, Dept Pharmacol, Konya, TurkiyeUniv Hlth Sci, Beyhekim Training & Res Hosp, Dept Pharmacol, Konya, Turkiye
Oktar, S.
[1
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Dogru, S.
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Gaziantep Univ, Med Sch, Dept Chest Dis, Gaziantep, TurkiyeUniv Hlth Sci, Beyhekim Training & Res Hosp, Dept Pharmacol, Konya, Turkiye
Dogru, S.
[2
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Motor, S.
[3
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Demirkose, M.
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Ankara Ataturk Sanatory Educ & Res Hosp, Dept Chest Dis, Ankara, TurkiyeUniv Hlth Sci, Beyhekim Training & Res Hosp, Dept Pharmacol, Konya, Turkiye
Demirkose, M.
[4
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Erden, E. S.
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Mustafa Kemal Univ, Med Sch, Dept Chest Dis, Hatay, TurkiyeUniv Hlth Sci, Beyhekim Training & Res Hosp, Dept Pharmacol, Konya, Turkiye
Erden, E. S.
[5
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机构:
[1] Univ Hlth Sci, Beyhekim Training & Res Hosp, Dept Pharmacol, Konya, Turkiye
[2] Gaziantep Univ, Med Sch, Dept Chest Dis, Gaziantep, Turkiye
[3] Mustafa Kemal Univ, Med Sch, Dept Biochem, Hatay, Turkiye
[4] Ankara Ataturk Sanatory Educ & Res Hosp, Dept Chest Dis, Ankara, Turkiye
[5] Mustafa Kemal Univ, Med Sch, Dept Chest Dis, Hatay, Turkiye
There are some indications in a few studies on animals and humans that the mucolytic agents N-acetylcysteine and erdosteine have a disruptive effect on the coagulation cascade. This study aimed to examine the effects of both erdosteine and N-acetylcysteine on the coagulation pathway.<br /> Materials and Methods. The research was conducted on patients treated with N-acetylcysteine (600 mg/day) or erdosteine (600 mg/day) for 7-14 days. To evaluate the coagulation and hemogram parameters, blood samples were taken from patients before treatment and on days 7-14 after starting the treatment. Hemogram and coagulation parameters were measured in the venous blood samples.<br /> Results. The levels of factor II significantly decreased, and the platelet count significantly increased in patients treated with erdosteine. D-dimer levels reduced and factor VII levels increased in patients treated with N-acetylcysteine, but these changes were not significant (p=0.069 and p=0.062, respectively). Other coagulation and hemogram values did not change in both groups. Erdosteine may have a dualistic effect on the coagulation cascade through its different metabolites.
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Univ Roma Tor Vergata, Dept Expt Med, Unit Resp Med, Via Montpellier 1, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Expt Med, Unit Resp Med, Via Montpellier 1, I-00133 Rome, Italy
Rogliani, Paola
Matera, Maria Gabriella
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Univ Campania Luigi Vanvitelli, Dept Expt Med, Unit Pharmacol, Naples, ItalyUniv Roma Tor Vergata, Dept Expt Med, Unit Resp Med, Via Montpellier 1, I-00133 Rome, Italy
Matera, Maria Gabriella
Page, Clive
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Kings Coll London, Inst Pharmaceut Sci, Sackler Inst Pulm Pharmacol, London, EnglandUniv Roma Tor Vergata, Dept Expt Med, Unit Resp Med, Via Montpellier 1, I-00133 Rome, Italy
Page, Clive
Puxeddu, Ermanno
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Univ Roma Tor Vergata, Dept Expt Med, Unit Resp Med, Via Montpellier 1, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Expt Med, Unit Resp Med, Via Montpellier 1, I-00133 Rome, Italy
Puxeddu, Ermanno
Cazzola, Mario
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Univ Roma Tor Vergata, Dept Expt Med, Unit Resp Med, Via Montpellier 1, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Expt Med, Unit Resp Med, Via Montpellier 1, I-00133 Rome, Italy
Cazzola, Mario
Calzetta, Luigino
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Univ Roma Tor Vergata, Dept Expt Med, Unit Resp Med, Via Montpellier 1, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Expt Med, Unit Resp Med, Via Montpellier 1, I-00133 Rome, Italy