The Effects of Mucolytic Agents N-Acetylcysteine and Erdosteine on Hemostasis in Humans

被引:0
|
作者
Oktar, S. [1 ]
Dogru, S. [2 ]
Motor, S. [3 ]
Demirkose, M. [4 ]
Erden, E. S. [5 ]
机构
[1] Univ Hlth Sci, Beyhekim Training & Res Hosp, Dept Pharmacol, Konya, Turkiye
[2] Gaziantep Univ, Med Sch, Dept Chest Dis, Gaziantep, Turkiye
[3] Mustafa Kemal Univ, Med Sch, Dept Biochem, Hatay, Turkiye
[4] Ankara Ataturk Sanatory Educ & Res Hosp, Dept Chest Dis, Ankara, Turkiye
[5] Mustafa Kemal Univ, Med Sch, Dept Chest Dis, Hatay, Turkiye
关键词
coagulation; platelet count; thrombocyte; N-acetylcysteine; erdosteine; PROTHROMBIN TIME; PLASMA SAMPLES; IN-VITRO; COAGULATION; BLOOD; HYPERHOMOCYSTEINEMIA; INFECTIONS; THROMBOSIS; RISK;
D O I
10.17691/stm2024.16.4.06
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
There are some indications in a few studies on animals and humans that the mucolytic agents N-acetylcysteine and erdosteine have a disruptive effect on the coagulation cascade. This study aimed to examine the effects of both erdosteine and N-acetylcysteine on the coagulation pathway.<br /> Materials and Methods. The research was conducted on patients treated with N-acetylcysteine (600 mg/day) or erdosteine (600 mg/day) for 7-14 days. To evaluate the coagulation and hemogram parameters, blood samples were taken from patients before treatment and on days 7-14 after starting the treatment. Hemogram and coagulation parameters were measured in the venous blood samples.<br /> Results. The levels of factor II significantly decreased, and the platelet count significantly increased in patients treated with erdosteine. D-dimer levels reduced and factor VII levels increased in patients treated with N-acetylcysteine, but these changes were not significant (p=0.069 and p=0.062, respectively). Other coagulation and hemogram values did not change in both groups. Erdosteine may have a dualistic effect on the coagulation cascade through its different metabolites.
引用
收藏
页码:55 / 60
页数:6
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