Migraine Causality in Alpha-1 Antitrypsin Deficiency

被引:0
|
作者
Demir Unal, Esra [1 ]
机构
[1] Nevsehir State Hosp, Neurol Clin, Nevsehir, Turkiye
关键词
Alpha-1 antitrypsin deficiency; cortical spreading depression; hepatocerebral pathways; migraine; neuroimmune activation; neuroinflammation;
D O I
10.18678/dtfd.1447131
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Alpha1-antitrypsin (A1AT) is an anti-inflammatory mediator with antiprotease activity associated with anti-inflammatory and immunomodulatory effects in various inflammatory conditions. A1AT deficiency (A1ATD) has been associated with various hyperinflammatory diseases, such as lung disease (emphysema and bronchiectasis), liver disease (chronic hepatitis, cirrhosis, and hepatoma), and skin diseases (panniculitis). Migraine with aura is one of the common migraine subtypes associated with neuroimmunologic activation and neuroinflammation which is associated with cortical spreading depression and glial hyperinflammation in etioradiopathogenesis, and the main mechanisms explained so far are hyperinflammation of pro-inflammatory mediators, sensitivity of trigeminal nerve fibers and pain-conjugated glial cells activation. In this case report, a causative perspective of migraine with aura and A1ATD was presented through etioradiopathogenetics mechanisms that show the central reflections of systemic hyperinflammatory processes, and the importance of peripheral hyperinflammatory conditions in migraine etiology was examined.
引用
收藏
页码:179 / 182
页数:4
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