Progress in Research on Inhibitors Targeting SARS-CoV-2 Main Protease (Mpro)

被引：4
|
作者：
Yang, Yue [1 ]
Luo, Yi-Dan [1 ]
Zhang, Chen-Bo [1 ]
Xiang, Yang [1 ,2 ]
Bai, Xin-Yue [1 ]
Zhang, Die [1 ]
Fu, Zhao-Ying [1 ]
Hao, Ruo-Bing [1 ]
Liu, Xiao-Long [1 ]
机构：
[1] Yanan Univ, Sch Med, Yanan 716000, Peoples R China
[2] Yanan Univ, Coll Phys Educ, Yanan 716000, Peoples R China
来源：
ACS OMEGA | 2024年 / 9卷 / 32期
关键词：
RESPIRATORY SYNDROME-CORONAVIRUS; PAPAIN-LIKE PROTEASE; COVALENT INHIBITORS; WITHANIA-SOMNIFERA; DISCOVERY; DESIGN; AGLYCONE; BAICALIN;
D O I：
10.1021/acsomega.4c03023
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Since 2019, the novel coronavirus (SARS-CoV-2) has caused significant morbidity and millions of deaths worldwide. The Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2 and its variants, has further highlighted the urgent need for the development of effective therapeutic agents. Currently, the highly conserved and broad-spectrum nature of main proteases (M-pro) renders them of great importance in the field of inhibitor study. In this study, we categorize inhibitors targeting M-pro into three major groups: mimetic, nonmimetic, and natural inhibitors. We then present the research progress of these inhibitors in detail, including their mechanism of action, antiviral activity, pharmacokinetic properties, animal experiments, and clinical studies. This review aims to provide valuable insights and potential avenues for the development of more effective antiviral drugs against SARS-CoV-2.
引用
收藏
页码：34196 / 34219
页数：24
相关论文
共 50 条
  • [1] Targeting allosteric pockets of SARS-CoV-2 main protease Mpro
    Bhat, Zahoor Ahmad
    Chitara, Dheeraj
    Iqbal, Jawed
    Sanjeev, B. S.
    Madhumalar, Arumugam
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2022, 40 (14): : 6603 - 6618
  • [2] Primer for Designing Main Protease (Mpro) Inhibitors of SARS-CoV-2
    Thakur, Abhishek
    Sharma, Gaurav
    Badavath, Vishnu Nayak
    Jayaprakash, Venkatesan
    Merz, Kenneth M., Jr.
    Blum, Galia
    Acevedo, Orlando
    JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 2022, 13 (25): : 5776 - 5786
  • [3] Research Progress of Antiviral Drug Targeting the Main Protease of SARS-CoV-2
    Wang, Chunxia
    Hu, Xiaodong
    Xu, Bin
    Cao, Chunyang
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2022, 42 (07) : 1974 - 1999
  • [4] Review on development of potential inhibitors of SARS-CoV-2 main protease (MPro)
    Soumya Gulab Katre
    Alpana Jagdish Asnani
    Kumar Pratyush
    Nilima Gangadhar Sakharkar
    Ashwini Gajanan Bhope
    Kanchan Tekram Sawarkar
    Vaibhav Santosh Nimbekar
    Future Journal of Pharmaceutical Sciences, 8
  • [5] Review on development of potential inhibitors of SARS-CoV-2 main protease (MPro)
    Katre, Soumya Gulab
    Asnani, Alpana Jagdish
    Pratyush, Kumar
    Sakharkar, Nilima Gangadhar
    Bhope, Ashwini Gajanan
    Sawarkar, Kanchan Tekram
    Nimbekar, Vaibhav Santosh
    FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES, 2022, 8 (01)
  • [6] In Silico Identification of Potential Inhibitors of SARS-CoV-2 Main Protease (Mpro)
    Hernandez-Serda, Manuel Alejandro
    Vazquez-Valadez, Victor H.
    Aguirre-Vidal, Pablo
    Markarian, Nathan M.
    Medina-Franco, Jose L.
    Cardenas-Granados, Luis Alfonso
    Alarcon-Lopez, Aldo Yoshio
    Martinez-Soriano, Pablo A.
    Velazquez-Sanchez, Ana Maria
    Falfan-Valencia, Rodolfo E.
    Angeles, Enrique
    Abrahamyan, Levon
    PATHOGENS, 2024, 13 (10):
  • [7] Statine-based peptidomimetic compounds as inhibitors for SARS-CoV-2 main protease (SARS-CoV-2 Mpro)
    Azevedo, Pedro Henrique R. de A.
    Camargo, Priscila G.
    Constant, Larissa E. C.
    Costa, Stephany da S.
    Silva, Celimar Sinezia
    Rosa, Alice S.
    Souza, Daniel D. C.
    Tucci, Amanda R.
    Ferreira, Vivian N. S.
    Oliveira, Thamara Kelcya F.
    Borba, Nathalia R. R.
    Rodrigues, Carlos R.
    Albuquerque, Magaly G.
    Dias, Luiza R. S.
    Garrett, Rafael
    Miranda, Milene D.
    Allonso, Diego
    Lima, Camilo Henrique da S.
    Muri, Estela Maris F.
    SCIENTIFIC REPORTS, 2024, 14 (01):
  • [8] In-silico drug repurposing for targeting SARS-CoV-2 main protease (Mpro)
    Sharma, Shilpa
    Deep, Shashank
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2022, 40 (07): : 3003 - 3010
  • [9] The Discovery of Novel Small Oxindole-Based Inhibitors Targeting the SARS-CoV-2 Main Protease (Mpro)
    Alzyoud, Lara
    Mahgoub, Radwa E.
    Mohamed, Feda E.
    Ali, Bassam R.
    Ferreira, Juliana
    Rabeh, Wael M.
    Atatreh, Noor
    Ghattas, Mohammad A.
    CHEMISTRY & BIODIVERSITY, 2023, 20 (11)
  • [10] Discovery of novel SARS-CoV-2 inhibitors targeting the main protease Mpro by virtual screenings and hit optimization
    Goracci, Laura
    Loregian, Arianna
    Mercorelli, Beatrice
    Desantis, Jenny
    Celegato, Marta
    Bazzacco, Alessandro
    Siragusa, Lydia
    Benedetti, Paolo
    Eleuteri, Michela
    Croci, Federico
    Cruciani, Gabriele
    ANTIVIRAL RESEARCH, 2022, 204
12345