Glucagon promotes hepatic autophagy by AMPK-mediated mTORC1 inhibition

被引：0
|
作者：
Galsgaard, K. D. [1 ]
Lee, J. [2 ]
Hubbard, B. T. [2 ]
Zhang, X. -M. [2 ]
Cline, G. W. [2 ]
Nasiri, A. R. [2 ]
Holst, J. J. [1 ]
Albrechtsen, N. J. Wewer [1 ]
Pertersen, K. F. [2 ]
Shulman, G. I. [2 ,3 ]
机构：
[1] Univ Copenhagen, Dept Biomed Sci, Copenhagen, Denmark
[2] Yale Sch Med, Dept Internal Med, New Haven, CT USA
[3] Yale Sch Med, Dept Cellular & Mol Physiol, New Haven, CT USA
来源：
DIABETOLOGIA | 2020年 / 63卷 / SUPPL 1期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
477
引用
收藏
页码：S231 / S232
页数：2
相关论文
共 50 条
  • [1] Glucagon Promotes Hepatic Autophagy by AMPK-Mediated mTORC1 Inhibition
    Galsgaard, Katrine D.
    Albrechtsen, Nicolai J. Wewer
    Holst, Jens J.
    Shulman, Gerald I.
    Petersen, Kitt
    Nasiri, Ali
    Cline, Gary
    Zhang, Xian-Man
    Lee, Ji Eun
    Hubbard, Brandon T.
    DIABETES, 2020, 69
  • [2] MLKL promotes hepatocarcinogenesis through inhibition of AMPK-mediated autophagy
    Yu, Xianjun
    Feng, Mengyuan
    Guo, Jian
    Wang, Haoyu
    Yu, Jun
    Zhang, Anjie
    Wu, Jingyi
    Han, Yamei
    Sun, Zequn
    Liao, Yingying
    Zhao, Qun
    CELL DEATH AND DIFFERENTIATION, 2024, 31 (08): : 1085 - 1098
  • [3] Cyclosporin A suppresses prostate cancer cell growth through CaMKKβ/AMPK-mediated inhibition of mTORC1 signaling
    Lee, Chae Ryun
    Chun, Jung Nyeo
    Kim, Sang-Yeob
    Park, Soonbum
    Kim, Su-Hwa
    Park, Eun-Jung
    Kim, In-San
    Cho, Nam-Hyuk
    Kim, In-Gyu
    So, Insuk
    Kim, Tae Woo
    Jeon, Ju-Hong
    BIOCHEMICAL PHARMACOLOGY, 2012, 84 (04) : 425 - 431
  • [4] Clearance of β-amyloid mediated by autophagy is enhanced by MTORC1 inhibition but not AMPK activation in APP/PSEN1 astrocytes
    Garcia-Juan, Marta
    Ordonez-Gutierrez, Lara
    Wandosell, Francisco
    GLIA, 2024, 72 (03) : 588 - 606
  • [5] MTORC1 inhibition drives crinophagic degradation of glucagon
    Rajak, Sangam
    Xie, Sherwin
    Tewari, Archana
    Raza, Sana
    Wu, Yajun
    Bay, Boon-Huat
    Yen, Paul M.
    Sinha, Rohit A.
    MOLECULAR METABOLISM, 2021, 53
  • [6] AMPK inhibits cardiac hypertrophy by promoting autophagy via mTORC1
    Li, Yanh
    Chen, Cong
    Yao, Fengj
    Su, Qiao
    Liu, Dan
    Xue, Ruic
    Dai, Gang
    Fang, Rong
    Zeng, Juny
    Chen, Yil
    Huang, Huil
    Ma, Yued
    Li, Wenw
    Zhang, Lil
    Liu, Chen
    Dong, Yug
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2014, 558 : 79 - 86
  • [7] Too Sweet for Autophagy: Hexokinase Inhibition of mTORC1 Activates Autophagy
    Kundu, Mondira
    MOLECULAR CELL, 2014, 53 (04) : 517 - 518
  • [8] Evaluation of hepatic AMPK, mTORC1, and autophagy-lysosomal pathway in cows with mild or moderate fatty liver
    Du, Xiliang
    Chen, Meng
    Fang, Zhiyuan
    Shao, Qi
    Yu, Hao
    Hao, Xue
    Gao, Xinxing
    Ju, Lingxue
    Li, Chenxu
    Yang, Yuting
    Song, Yuxiang
    Lei, Lin
    Liu, Guowen
    Li, Xinwei
    JOURNAL OF DAIRY SCIENCE, 2024, 107 (05) : 3269 - 3279
  • [9] AMPK activation does not enhance autophagy in neurons in contrast to MTORC1 inhibition: different impact on β-amyloid clearance
    Benito-Cuesta, Irene
    Ordonez-Gutierrez, Lara
    Wandosell, Francisco
    AUTOPHAGY, 2021, 17 (03) : 656 - 671
  • [10] Fructose-Induced mTORC1 Activation Promotes Pancreatic Cancer Progression through Inhibition of Autophagy
    Cui, Yanfen
    Tian, Jianfei
    Wang, Zhaosong
    Guo, Hui
    Zhang, He
    Wang, Zhiyong
    Liu, Hui
    Song, Weijie
    Liu, Liming
    Tian, Ruinan
    Zuo, Xiaoyan
    Ren, Sixin
    Niu, Ruifang
    Zhang, Fei
    CANCER RESEARCH, 2023, 83 (24) : 4063 - 4079
12345