This study has investigated the co-disposal of municipal solid waste (MSW) and coal via a gasification-based route for a co-generation of heat, power, and syngas. Through utilizing the Aspen Plus software, the thermodynamic performance, energy, and exergy of co-process were carefully discussed, and the sensitivity analyses of distinct operating parameters of the coal-to-MSW blending ratios (C/M), reaction temperatures (RT), equivalence air coefficients (EAC), as well as the MSW moisture contents, were further conducted to chemical compositions of gasification products and their calorific value (Qsyngas), cold gas efficiency (eta G), carbon conversion efficiency (eta C), as well as energy and exergy efficiencies (eta en and eta ex) of the system. The results indicated that the optimal coal blending ratio was 0.5, yielding maximum eta en and eta ex of 82.47% and 75.09%, separately. The RT significantly impacted the process performances and 800.0 degrees C was the optimal value. The values of eta en and eta ex first increased and then decreased with the EAC increasing, and the optimal value was 0.20, resulting in corresponding maximum eta en and eta ex of 82.47% and 75.09%, respectively. With optimal conditions identified at the coal blending ratio of 0.5, RT of 800.0 degrees C, EAC of 0.20, and moisture content of MSW of 25%, and yielded the highest eta en and eta ex of process, the values were separately 83.29% and 75.79%. The study will give some valuable guide for the co-gasification disposal of MSW.