Lipid Nanoparticles for Nucleic Acid Delivery Beyond the Liver

被引:1
|
作者
Saber, Nadine [1 ]
Senti, Mariona Estape [1 ]
Schiffelers, Raymond M. [1 ]
机构
[1] Univ Med Ctr Utrecht, CDL Res, Heidelberglaan 100, NL-3584 Utrecht, Netherlands
关键词
nanomedicine; lipid nanoparticle; drug delivery; extrahepatic delivery; gene therapy; nucleic acid; targeted delivery; HEMATOPOIETIC STEM; RNA DELIVERY; CELLS; PEG; THERAPEUTICS; PERMEABILITY; PEGYLATION; ANTIBODIES; SYSTEMS; LIGAND;
D O I
10.1089/hum.2024.106
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Lipid nanoparticles (LNPs) are the most clinically advanced drug delivery system for nucleic acid therapeutics, exemplified by the success of the COVID-19 mRNA vaccines. However, their clinical use is currently limited to hepatic diseases and vaccines due to their tendency to accumulate in the liver upon intravenous administration. To fully leverage their potential, it is essential to understand and address their liver tropism, while also developing strategies to enhance delivery to tissues beyond the liver. Ensuring that these therapeutics reach their target cells while avoiding off-target cells is essential for both their efficacy and safety. There are three potential targeting strategies-passive, active, and endogenous-which can be used individually or in combination to target nonhepatic tissues. In this review, we delve into the recent advancements in LNP engineering for delivering nucleic acid beyond the liver.
引用
收藏
页码:617 / 627
页数:11
相关论文
共 50 条
  • [1] Surface engineering of lipid nanoparticles: targeted nucleic acid delivery and beyond
    Yi Lin
    Qiang Cheng
    Tuo Wei
    Biophysics Reports, 2023, 9 (05) : 255 - 278
  • [3] Lipid Nanoparticles for Nucleic Acid Delivery to Endothelial Cells
    Gary W. Liu
    Edward B. Guzman
    Nandita Menon
    Robert S. Langer
    Pharmaceutical Research, 2023, 40 : 3 - 25
  • [4] Lipid Nanoparticles With Low Immunogenicity For Nucleic Acid Delivery
    Couture-Senecal, J.
    Tilstra, G.
    Khan, O. F.
    TISSUE ENGINEERING PART A, 2022, 28 : 346 - 347
  • [5] Lipid-based Nanoparticles for Nucleic Acid Delivery
    Weijun Li
    Francis C. Szoka
    Pharmaceutical Research, 2007, 24 : 438 - 449
  • [6] Lipid-based nanoparticles for nucleic acid delivery
    Li, Weijun
    Szoka, Francis C., Jr.
    PHARMACEUTICAL RESEARCH, 2007, 24 (03) : 438 - 449
  • [7] Lipid nanoparticles for nucleic acid delivery: Current perspectives
    Samaridou, Eleni
    Heyes, James
    Lutwyche, Peter
    ADVANCED DRUG DELIVERY REVIEWS, 2020, 154 : 37 - 63
  • [8] Lipid Nanoparticles for Nucleic Acid Delivery to Endothelial Cells
    Liu, Gary W.
    Guzman, Edward B.
    Menon, Nandita
    Langer, Robert S.
    PHARMACEUTICAL RESEARCH, 2023, 40 (01) : 3 - 25
  • [9] Long-Circulating Lipid Nanoparticles for Agnostic Nucleic Acid Delivery to the Bone Marrow and Beyond
    An, Kevin
    Kurek, Daniel
    Cullis, Pieter R.
    Witzigmann, Dominik
    Kulkarni, Jayesh A.
    MOLECULAR THERAPY, 2023, 31 (04) : 44 - 45
  • [10] Functionalized lipid-nucleic acid nanoparticles for delivery applications
    Safinya, Cyrus
    Majzoub, Ramsey
    Ewert, Kai
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 249