High rates of anal Merkel Cell Polyomavirus and HPV co-infection among people living with HIV

被引：0

作者：

Passerini, Sara ^{[1
]}

Fracella, Matteo ^{[2
]}

Benvenuto, Domenico ^{[3
]}

Bugani, Ginevra ^{[1
]}

D'Auria, Alessandra ^{[2
]}

Coratti, Eleonora ^{[2
]}

Babini, Giulia ^{[1
]}

Moens, Ugo ^{[4
]}

Cavallari, Eugenio Nelson ^{[1
]}

Torti, Carlo ^{[3
,5
]}

Antonelli, Guido ^{[2
]}

Ciccozzi, Massimo ^{[6
]}

Pierangeli, Alessandra ^{[2
]}

d'Ettorre, Gabriella ^{[1
]}

Scagnolari, Carolina ^{[2
]}

Pietropaolo, Valeria ^{[1
]}

机构：

[1] Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, I-00185 Rome, Italy

[2] Sapienza Univ Rome, Dept Mol Med, Lab Virol, I-00185 Rome, Italy

[3] Univ Cattolica Sacro Cuore, Dipartimento Sicurezza & Bioet, Sez Malattie Infett, Rome, Italy

[4] Univ Tromso, Arctic Univ Norway, Fac Hlth Sci, Dept Med Biol, Tromso, Norway

[5] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Sci Lab & Infettivolog, Rome, Italy

[6] Univ Campus Biomed Rome, Unit Med Stat & Mol Epidemiol, Rome, Italy

来源：

JOURNAL OF MEDICAL VIROLOGY | 2024年 / 96卷 / 08期

关键词：

HIV; HPV; HPyV; HUMAN-PAPILLOMAVIRUS; DNA;

D O I：

10.1002/jmv.29883

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Knowledge of Human Polyomavirus (HPyV) infection in the anal area and its association with sexually transmitted infections such as Human Papillomavirus (HPV) and Human Immunodeficiency Virus (HIV) remains limited. Therefore, anal specimens from 150 individuals of both sexes were analyzed for screening purposes. HPV DNA was found in 50.7% of cases, with a predominance of high-risk (HR) genotypes. HPyV DNA was found in 39.3% of samples, with Merkel Cell Polyomavirus (MCPyV) being the most common, with a higher viral load than JCPyV and BKPyV. In addition, MCPyV viral load increased in people living with HIV (PLWH) with HPV infection (p < 0.0001).

引用

页数：6

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