The Health Care Systems Research Network (HCSRN) comprises 20 learning health systems with integrated care delivery and embedded research units. The network's annual conference serves as a forum for research teams from member institutions to disseminate project findings, explore scientific collaborations, and share insights about population-based research practices that can measurably improve health and health care for all. The theme of this year's conference was "Advancing high-quality, equitable research in the age of new health care technologies." Abstracts presented at HCSRN 2024 are published in this issue supplement of the Journal of Patient-Centered Research and Reviews, the journal of record for HCSRN's annual conference proceedings.