Mitochondria as therapeutic targets in assisted reproduction

被引:5
|
作者
Yildirim, Raziye Melike [1 ]
Seli, Emre [1 ]
机构
[1] Yale Sch Med, Dept Obstet Gynecol & Reprod Sci, 200 West Campus Dr,2nd Floor Room 211, Orange, CT 06477 USA
关键词
mtDNA; in vitro fertilization; oocyte; embryo; antioxidants; ROS; mitochondrial replacement therapies; maternal spindle transfer (MST); pronuclear transfer (PNT); IN-VITRO MATURATION; ENHANCES DEVELOPMENTAL COMPETENCE; COENZYME-Q10; SUPPLEMENTATION; PRONUCLEAR TRANSFER; GENOME TRANSFER; DNA MUTATIONS; MOUSE OOCYTES; PIG OOCYTES; RESVERATROL; HETEROPLASMY;
D O I
10.1093/humrep/deae170
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Mitochondria are essential organelles with specialized functions, which play crucial roles in energy production, calcium homeostasis, and programmed cell death. In oocytes, mitochondrial populations are inherited maternally and are vital for developmental competence. Dysfunction in mitochondrial quality control mechanisms can lead to reproductive failure. Due to their central role in oocyte and embryo development, mitochondria have been investigated as potential diagnostic and therapeutic targets in assisted reproduction. Pharmacological agents that target mitochondrial function and show promise in improving assisted reproduction outcomes include antioxidant coenzyme Q10 and mitoquinone, mammalian target of rapamycin signaling pathway inhibitor rapamycin, and nicotinamide mononucleotide. Mitochondrial replacement therapies (MRTs) offer solutions for infertility and mitochondrial disorders. Autologous germline mitochondrial energy transfer initially showed promise but failed to demonstrate significant benefits in clinical trials. Maternal spindle transfer (MST) and pronuclear transfer hold potential for preventing mitochondrial disease transmission and improving oocyte quality. Clinical trials of MST have shown promising outcomes, but larger studies are needed to confirm safety and efficacy. However, ethical and legislative challenges complicate the widespread implementation of MRTs. Graphical Abstract Therapeutic use of mitochondria in assisted reproduction. Autologous germline mitochondrial energy transfer (AUGMENT). Created with BioRender.com.
引用
收藏
页码:2147 / 2159
页数:13
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