'Turning On' to Glutathione: A Rhodamine-Based Fluorescent Chemodosimeter with Nanomolar Sensitivity

被引：0
|
作者：
Badekar, Pooja S. [1 ]
Deo, Harshada S. [1 ]
Varma, Mokshada E. [2 ]
Kulkarni, Prasad P. [2 ]
Maibam, Ashakiran [3 ]
Krishnamurty, Sailaja [3 ]
Kumbhar, Anupa A. [1 ]
机构：
[1] Savitribai Phule Pune Univ, Dept Chem, Ganeshkhind Rd, Pune 411007, India
[2] Agharkar Res Inst, Bioprospecting Grp, Gopal Ganesh Agarkar Rd, Pune 411004, India
[3] CSIR Natl Chem Lab, Phys Chem Div, Dr Homi Bhabha Rd, Pune 411008, India
来源：
CHEMISTRYSELECT | 2024年 / 9卷 / 37期
关键词：
Chemodosimeter; Fluorescence turn-on; GSH; MCF-7; cells; Rhodamine; SELECTIVE DETECTION; LIVING CELLS; PROBE; CYSTEINE; CONJUGATE; GSH;
D O I：
10.1002/slct.202402943
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new colorimetric and fluorescence turn-on chemodosimeter for selective detection of GSH over Cys and Hcy with 34-fold enhancement in emission intensity is reported. Probe 1 exhibited ultra-sensitivity toward GSH with 0.125 nM detection limit and successfully displayed GSH detection in MCF-7 live cells. The mechanism of sensing is established by density functional theoretical calculations.
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页数：5
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