Late-onset vitamin K deficiency presenting as haemorrhagic shock and severe multi-system organ failure
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作者:
Azar, Justin M.
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机构:
Janet Weis Childrens Hosp, Danville, PA 17822 USA
Geisinger Commonwealth Sch Med, Pediat, Scranton, PA 18509 USAJanet Weis Childrens Hosp, Danville, PA 17822 USA
Azar, Justin M.
[1
,2
]
Lambert, Richard
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机构:
Janet Weis Childrens Hosp, Danville, PA 17822 USA
Geisinger Commonwealth Sch Med, Pediat, Scranton, PA 18509 USAJanet Weis Childrens Hosp, Danville, PA 17822 USA
Lambert, Richard
[1
,2
]
Maffei, Frank Anthony
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机构:
Janet Weis Childrens Hosp, Danville, PA 17822 USA
Geisinger Commonwealth Sch Med, Pediat, Scranton, PA 18509 USAJanet Weis Childrens Hosp, Danville, PA 17822 USA
Maffei, Frank Anthony
[1
,2
]
Thomas, Tessy A.
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h-index: 0
机构:
Janet Weis Childrens Hosp, Danville, PA 17822 USA
Geisinger Commonwealth Sch Med, Pediat, Scranton, PA 18509 USAJanet Weis Childrens Hosp, Danville, PA 17822 USA
Thomas, Tessy A.
[1
,2
]
机构:
[1] Janet Weis Childrens Hosp, Danville, PA 17822 USA
[2] Geisinger Commonwealth Sch Med, Pediat, Scranton, PA 18509 USA
Preventative pediatrics;
Neonatal and paediatric intensive care;
Routine care of the full-time infant;
Infant health;
Haematology (incl blood transfusion);
INTRACRANIAL HEMORRHAGE;
THYMIC HEMORRHAGE;
INFANTS;
DISEASE;
D O I:
10.1136/bcr-2024-261126
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Vitamin K is an essential dietary cofactor required for the synthesis of active forms of vitamin K-dependent procoagulant proteins. Vitamin K deficiency, particularly late-onset deficiency occurring between 1 week and 6 months of age, can cause a life-threatening bleeding disorder. An exclusively breastfed, full-term, 6-week-old infant male presented with severe haemorrhagic shock and multi-system organ failure related to caregiver refusal of intramuscular vitamin K after birth. Coagulation studies were normalised within 8 hours of intramuscular vitamin K administration. An increasing number of caregivers are refusing intramuscular vitamin K which has led to a rise in the incidence of vitamin K deficiency bleeding. Health policy organisations around the world emphasise the benefits of intramuscular vitamin K and risks of refusal, particularly in exclusively breastfed infants who are at higher risk due to low vitamin K levels in breast milk. This case highlights the multi-system severity of this life-threatening yet preventable disorder.
机构:
Univ Utah, Dept Pediat, 100 Mario Capecchi Dr, Salt Lake City, UT 84103 USAUniv Utah, Dept Pediat, 100 Mario Capecchi Dr, Salt Lake City, UT 84103 USA
Wolpert, Katherine
Szadkowski, Matthew
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机构:
Univ Utah, Div Pediat Emergency Med, Salt Lake City, UT USAUniv Utah, Dept Pediat, 100 Mario Capecchi Dr, Salt Lake City, UT 84103 USA
Szadkowski, Matthew
Miescier, Michael
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机构:
Univ Utah, Div Pediat Emergency Med, Salt Lake City, UT USAUniv Utah, Dept Pediat, 100 Mario Capecchi Dr, Salt Lake City, UT 84103 USA
Miescier, Michael
Hewes, Hilary A.
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机构:
Univ Utah, Div Pediat Emergency Med, Salt Lake City, UT USAUniv Utah, Dept Pediat, 100 Mario Capecchi Dr, Salt Lake City, UT 84103 USA