Rothia mucilaginosa Pneumonia in an Immunocompromised Patient: Diagnosis With Plasma Microbial Cell-Free DNA Next-Generation Sequencing and Treatment With Eravacycline

被引：0

作者：

Gelfand, Michael S. ^{[1
]}

Cleveland, Kerry O. ^{[1
]}

Animalu, Chinelo ^{[1
]}

机构：

[1] Univ Tennessee, Hlth Sci Ctr, Div Infect Dis, Dept Med, 1325 Easmoreland Ave,Ste 460, Memphis, TN 38104 USA

来源：

INFECTIOUS DISEASES IN CLINICAL PRACTICE | 2024年 / 32卷 / 06期

关键词：

Rothia pneumonia; eravacycline; next-generation sequencing; BACTEREMIA; EXPERIENCE;

D O I：

10.1097/IPC.0000000000001410

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rothia mucilaginosa is a gram-positive coccus recognized as an opportunistic pathogen capable of causing pneumonia in immunocompromised patients (Antimicrob Agents Chemother. 1995;39:268-270). The organism is often resistant to fluoroquinolones and trimethoprim/sulfamethoxazole, agents routinely used as anti-infective prophylaxis in immunocompromised individuals (Inf Dis Clin Pract. 2020;28:361-365; Infect Dis Now. 2021;51:228-235). Plasma next-generation sequencing (NGS) is increasing in clinical use to aid in diagnosis of infections in immunocompromised patients (Infect Dis (Lond). 2015;47:125-1299). A patient with advanced multiple myeloma was admitted with pneumonia. Plasma NGS initially suggested R. mucilaginosa, which was confirmed by cultures of bronchoalveolar lavage (BAL) fluid. Treatment with eravacycline led to clinical and radiographic resolution of pneumonia.

引用

页数：2

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