Downsides to the empathic brain? A review of neural correlates of empathy in major depressive disorder

被引:0
|
作者
Choi, Dahna [1 ]
Foerster, Katharina [1 ]
Alexander, Nina [2 ,3 ]
Kanske, Philipp [1 ]
机构
[1] Tech Univ Dresden, Inst Clin Psychol & Psychotherapy, Clin Psychol & Behav Neurosci, Dept Psychol, Dresden, Germany
[2] Univ Marburg, Dept Psychiat & Psychotherapy, Marburg, Germany
[3] Univ Marburg, Ctr Mind Brain & Behav, Marburg, Germany
来源
关键词
major depressive disorder; social cognition; empathy; neural correlates; fMRI; EMOTION REGULATION; SOCIAL COGNITION; PAIN; STIMULATION; NETWORKS; BEHAVIOR; ROUTES; OTHERS;
D O I
10.3389/fnhum.2024.1456570
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Empathy as one of the basic prerequisites for successful social interactions seems to be aberrant in individuals with major depressive disorder (MDD). Although understanding empathic impairments in MDD is crucial considering the frequently reported social skill deficits in patients, the current state of research is still inconclusive, pointing to both elevated and impaired levels of empathy. In this review, we extend previous reports of MDD-related aberrations in self-reported and behavioral empathy by shedding light on the neural correlates of empathy in MDD. Study findings indicate a complex and potentially state-dependent association, comprising both elevated and lower neural activity in empathy-related brain regions such as the inferior frontal gyri, bilateral anterior insulae, and cingulate areas. Predominantly, lower activity in these areas seems to be induced by antidepressant treatment or remission, with accompanying behavioral results indicating a reduced negativity-bias in empathic processing compared to acute states of MDD. We propose a preliminary model of empathy development throughout the course of the disorder, comprising initially elevated levels of empathy and a somewhat detached and lower empathic responding during the further progression of the disorder or post-treatment. The seemingly multifaceted nature of the association between empathy and MDD requires further exploration in future multimodal and longitudinal studies. The study of neural correlates of empathy in MDD should prospectively be enlarged by including further socio-affective and -cognitive capacities in MDD and related mental disorders.
引用
收藏
页数:7
相关论文
共 50 条
  • [1] Neural correlates of rumination in major depressive disorder: A brain network analysis
    Jacob, Yael
    Morris, Laurel S.
    Huang, Kuang-Han
    Schneider, Molly
    Rutter, Sarah
    Verma, Gaurav
    Murrough, James W.
    Balchandani, Priti
    NEUROIMAGE-CLINICAL, 2020, 25
  • [2] Neural correlates of remission in major depressive disorder
    Scharinger, C.
    Hartinger, B.
    Diers, K.
    Rabl, U.
    Bartova, T.
    Sitte, H.
    Windischberger, C.
    Moser, E.
    Brocke, B.
    Kasper, S.
    Pezawas, L.
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2012, 15 : 196 - 196
  • [3] The neural correlates of anhedonia in major depressive disorder
    Keedwell, PA
    Andrew, C
    Williams, SCR
    Brammer, MJ
    Phillips, ML
    BIOLOGICAL PSYCHIATRY, 2005, 58 (11) : 843 - 853
  • [4] NEURAL CORRELATES OF COGNITIVE CONTROL IN MAJOR DEPRESSIVE DISORDER
    Bruehl, A.
    Rufer, M.
    Baur, V.
    Kaffenberger, T.
    Herwig, U.
    EUROPEAN PSYCHIATRY, 2010, 25
  • [5] Prevalence and correlates of major depressive disorder: a systematic review
    Gutierrez-Rojas, Luis
    Porras-Segovia, Alejandro
    Dunne, Henry
    Andrade-Gonzalez, Nelson
    Cervilla, Jorge A.
    BRAZILIAN JOURNAL OF PSYCHIATRY, 2020, 42 (06) : 657 - 672
  • [6] Brain structural correlates of alexithymia in patients with major depressive disorder
    Foerster, Katharina
    Enneking, Verena
    Dohm, Katharina
    Redlich, Ronny
    Meinert, Susanne
    Geisler, Adina Isabel
    Leehr, Elisabeth Johanna
    Kugel, Harald
    Baune, Bernhard T.
    Arolt, Volker
    Zwitserlood, Pienie
    Grotegerd, Dominik
    Dannlowski, Udo
    JOURNAL OF PSYCHIATRY & NEUROSCIENCE, 2020, 45 (02): : 117 - 124
  • [7] The neural correlates of anhedonia, anxiety and negative cognitions in major depressive disorder
    Keedwell, PA
    Andrew, C
    Steve, W
    Brammer, M
    Phillips, ML
    BIOLOGICAL PSYCHIATRY, 2005, 57 (08) : 8S - 8S
  • [8] Neural Correlates of Antidepressant Treatment Response in Adolescents with Major Depressive Disorder
    Cullen, Kathryn R.
    Klimes-Dougan, Bonnie
    Dung Pham Vu
    Schreiner, Melinda Westlund
    Mueller, Bryon A.
    Eberly, Lynn E.
    Camchong, Jazmin
    Westervelt, Ana
    Lim, Kelvin O.
    JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, 2016, 26 (08) : 705 - 712
  • [9] Alterations in neural correlates of autonomic control in females with major depressive disorder
    Nugent, Allison C.
    Bain, Earle E.
    Thayer, Julian F.
    Sollers, John J.
    Drevets, Wayne C.
    BIOLOGICAL PSYCHIATRY, 2008, 63 (07) : 210S - 210S
  • [10] Alterations in neural correlates of autonomic control in females with major depressive disorder
    Nugent, A. C.
    Bain, E. E.
    Thayer, J. F.
    Sollers, J. J.
    Drevets, W. C.
    INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 2008, 69 (03) : 195 - 195