Air pollutants and the risk of incident hepatobiliary diseases: A large prospective cohort study in the UK Biobank

The association between air pollutants and hepatobiliary pancreatic diseases remains inconclusive. This study analyzed up to 247,091 participants of White European ancestry (aged 37 to 73 years at recruitment) from the UK Biobank, a large-scale prospective cohort with open access. An air pollution score was utilized to assess the combined effect of PM2.5, 2.5 , PM 2.5-10 , PM10, 10 , NO2, 2 , and NOX X on total hepatobiliary pancreatic diseases, liver diseases, cholecyst diseases, and pancreatic diseases. Cox proportional hazard models were employed to evaluate the relationships between air pollutants and the incidence of these diseases. Restricted cubic spline regressions were used to examine the dose-response association between air pollutants and the risk of hepatobiliary pancreatic diseases. We identified 4865 cases of total hepatobiliary pancreatic diseases, over a median follow-up of 10.86 years. The air pollution scores were moderately associated with increased liver disease risk (HR = 1.009, 95 % CI: 1.004, 1.014), but not with cholecyst and pancreatic diseases. Among the individual air pollutants, PM 2.5 (HR = 1.069, 95 % CI: 1.025, 1.115) and PM10 10 (HR = 1.036, 95 % CI: 1.011, 1.061) significantly increased liver disease risk. Males showed a higher risk of liver diseases with PM 2.5 (HR = 1.075, 95 % CI: 1.015, 1.139). Additionally, individuals with overweight (HR = 1.125, 95% CI: 1.052, 1.203), age >= 60 and <= 73 (HR = 1.098, 95 % CI: 1.028, 1.172), and alcohol intake >= 14 unit/week (HR = 1.078, 95% CI: 1.006, 1.155) had a higher risk of developing liver diseases at high expose to PM2.5. 2.5 . This study suggests that prolonged exposure to ambient air pollutants may elevate the risk of liver diseases.