Evolving Management of Breast Cancer in the Era of Predictive Biomarkers and Precision Medicine

被引:1
|
作者
Afzal, Muhammad Zubair [1 ]
Vahdat, Linda T. [2 ]
机构
[1] Dartmouth Canc Ctr, Comprehens Breast Program, Med Oncol, Lebanon, NH 03755 USA
[2] Dartmouth Canc Ctr, Med Oncol & Hematol Interim, Lebanon, NH 03755 USA
来源
JOURNAL OF PERSONALIZED MEDICINE | 2024年 / 14卷 / 07期
关键词
personalized medicine; biomarkers; tumor microenvironment; immune contexture; CIRCULATING TUMOR DNA; INFILTRATING LYMPHOCYTES TILS; TRASTUZUMAB PLUS PACLITAXEL; ACTIVATING ESR1 MUTATIONS; ESTROGEN-RECEPTOR-ALPHA; PHASE-III; ENDOCRINE RESISTANCE; DOSE-ESCALATION; EMTANSINE T-DM1; HER2; MUTATIONS;
D O I
10.3390/jpm14070719
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Breast cancer is the most common cancer among women in the world as well as in the United States. Molecular and histological differentiation have helped clinicians optimize treatments with various therapeutics, including hormonal therapy, chemotherapy, immunotherapy, and radiation therapy. Recently, immunotherapy has become the standard of care in locally advanced triple-negative breast cancer and an option across molecular subtypes for tumors with a high tumor mutation burden. Despite the advancements in personalized medicine directing the management of localized and advanced breast cancers, the emergence of resistance to these therapies is the leading cause of death among breast cancer patients. Therefore, there is a critical need to identify and validate predictive biomarkers to direct treatment selection, identify potential responders, and detect emerging resistance to standard therapies. Areas of active scientific and clinical research include novel personalized and predictive biomarkers incorporating tumor microenvironment, tumor immune profiling, molecular characterization, and histopathological differentiation to predict response and the potential emergence of resistance.
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页数:32
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