Because practice research's benefits in social work contexts are well-documented, research attention has shifted to improving its operationalisation within organisations. However, few studies have examined practice research's challenges and opportunities across project conceptualisation, implementation, and dissemination. Even fewer have considered practitioner-researcher and organisational power dynamics, especially in Asia. Using a qualitative exploratory case study approach, we first described the challenges a Singaporean youth work agency faced during conceptualisation, implementation, and dissemination across three practice-research projects. Subsequently, we evaluated how the core practice-research team seized opportunities to address these challenges (i.e. manpower and resourcing, disproportionate researcher influence, sustaining interest internally and externally) and future improvement opportunities (i.e. institutionalise knowledge, build organisational capacity, and examine structural impediments). Implications for practitioners and researchers and effective organisational strategies - internally, externally, and structurally - are discussed.