Prevalence of Antimicrobial Resistance in Klebsiella pneumoniae, Enterobacter cloacae, and Escherichia coli Isolates among Stillbirths and Deceased Under-Five Children in Sierra Leone: Data from the Child Health and Mortality Prevention Surveillance Sites from 2019 to 2022

被引：0

作者：

Ojulong, Julius ^{[1
]}

Gebru, Gebrekrstos N. ^{[2
]}

Duduyemi, Babatunde ^{[3
]}

Gbenda, Edwin ^{[1
]}

Janneh, Mohamed L. ^{[1
]}

Sharty, Jack ^{[1
]}

Monteiro, Leonel ^{[4
]}

Kowuor, Dickens ^{[1
]}

Ameh, Soter ^{[1
,4
,5
]}

Ogbuanu, Ikechukwu U. ^{[1
,6
]}

机构：

[1] Emory Univ, Emory Global Hlth Inst, CHAMPS Program Off, Atlanta, GA 30322 USA

[2] Africa Field Epidemiol Network, Sierra Leone Field Epidemiol Training Program, Freetown 232, Sierra Leone

[3] Univ Sierra Leone, Coll Med & Allied Hlth Sci, Freetown 232, Sierra Leone

[4] Univ Calabar, Fac Med, Dept Community Med, Calabar 540281, Nigeria

[5] Harvard TH Chan Sch Publ Hlth, Dept Global Hlth & Populat, Bernard Lown Scholars Program Cardiovasc Hlth, Boston, MA 02115 USA

[6] Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA 30322 USA

来源：

MICROORGANISMS | 2024年 / 12卷 / 08期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

Klebsiella pneumoniae; Enterobacter cloacae; Escherichia coli; CHAMPS; extended spectrum beta-lactamase; Sierra Leone; PROFILES; PATIENT;

D O I：

10.3390/microorganisms12081657

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Klebsiella pneumoniae, Escherichia coli, and Enterobacter cloacae are associated with most nosocomial infections worldwide. Although gaps remain in the knowledge of their susceptibility patterns, these are in antimicrobial stewardship. This study aimed to describe antimicrobial susceptibility profiles of the above organisms isolated from postmortem blood from stillbirths and under-five children enrolled in the Child Health and Mortality Prevention Surveillance (CHAMPS) program in Sierra Leone. This was a surveillance study of bacteria isolates from postmortem blood cultures taken within 24 h of death from stillbirths and children aged 0-59 months between March 2019 and February 2022. This was followed by identification and antibiotic sensitivity testing using Becton Dickinson Phoenix M50 (USA). Descriptive analysis was used to characterize the isolates and their antimicrobial susceptibility patterns. Of 367 isolates, K. pneumoniae was the most frequently isolated organism (n = 152; 41.4%), followed by E. coli (n = 40; 10.9%) and E. cloacae (n = 35; 9.5%). Using BACTEC (TM) FX 40 (Franklin Lakes, NJ, USA), 367 isolates were identified from blood using bacteriological methods. Extended spectrum beta-lactamase (ESBL) was observed in 143 (94.1%) of K. pneumoniae isolates and 27 (65.5%) of E. coli isolates. Carbapenem-resistant organisms (CRO) were seen in 31 (20.4%) of K. pneumoniae and 5 (12.5%) of E. coli isolates. A multidrug resistance (MDR) pattern was most prevalent in E.cloacae (33/35; 94.3%), followed by K. pneumoniae (138/152; 90.8%). Our study showed a high prevalence of multidrug resistance among bacterial isolates in the catchment areas under surveillance by the CHAMPS sites in Sierra Leone.

引用

页数：10