Association of rs2241766 and rs1501299 polymorphisms in the adiponectin gene with metabolic syndrome

Objective:To investigate the influence of adiponectin (APN) rs2241766 andrs1501299 polymorphisms on adiponectin levels and their association withmetabolic syndrome (MetS). Methods:Analyzed two polymorphisms (rs2241766 and rs1501299) of theadiponectin gene (ADIPOQ) in 210 MetS patients and 102 control patientsusing the polymerase chain reaction-restriction fragment length polymor-phism method and DNA sequencing technology. Results:The genotypes of the rs2241766 T/G and rs1501299 G/T polymorphismwere significantly associated with serum APN levels in MetS patients. The ADIPOQpolymorphisms were associated with a risk of MetS when compared with that inhealthy controls. TG and GG genotypes of rs2241766 were associated with a sig-nificantly elevated risk of MetS as compared with the TT genotype (OR = 1.32 andOR = 2.53). Subjects with the G allele appeared to have higher susceptibility toMetS than those with the T allele (OR = 2.21). In common with the findings forrs2241766, the rs1501299 GT and TT genotypes were associated with a significantlyincreased risk of MetS as compared with the GG genotype (OR = 1.51 and OR =2.24). The susceptibility to MetS appeared to be higher in subjects with the T allelethan in those with the G allele (OR = 1.88). Conclusions:The occurrence of MetS may be associated with genetic varia-tions at the rs2241766 and rs1501299 loci, especially in individuals with T to Gmutations (rs2241766) and G to T mutations (rs1501299). These mutationsmay lead to decreased APN levels and a higher risk of developing MetS.