The Role of Nonhuman Primates in Neurotoxicology Research: Preclinical Models and Experimental Methods

被引：0
|
作者：
Petroff, Rebekah L. [1 ]
Grant, Kimberly S. [1 ]
Burbacher, Thomas M. [1 ]
机构：
[1] Univ Washington, Dept Environm & Occupat Hlth Sci DEOHS, Seattle, WA 98195 USA
来源：
CURRENT PROTOCOLS | 2023年 / 3卷 / 03期
基金：
美国国家卫生研究院;
关键词：
macaque; neurotoxicology; nonhuman primates; preclinical models; VISUAL RECOGNITION MEMORY; PRENATAL METHYLMERCURY EXPOSURE; BRAIN REGIONAL CHANGES; RHESUS-MONKEYS; MACACA-FASCICULARIS; LEAD-EXPOSURE; PARKINSONS-DISEASE; MANGANESE CONCENTRATIONS; DISCRIMINATION REVERSAL; CYNOMOLGUS MONKEYS;
D O I：
10.1002/cpz1.698
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Although noteworthy progress has been made in developing alternatives to animal testing, nonhuman primates still play a critical role in advancing biomedical research and will likely do so for many years. Core similarities between monkeys and humans in genetics, physiology, reproduction, development, and behavior make them excellent models for translational studies relevant to human health. This unit is designed to specifically address the role of nonhuman primates in neurotoxicology research and outlines the specialized assessments that can be used to measure exposure-related changes at the structural, chemical, cellular, molecular, and functional levels. (c) 2023 Wiley Periodicals LLC.
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页数：19
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