Molecular insights to therapeutic in cancer: role of exosomes in tumor microenvironment, metastatic progression and drug resistance

被引：5
|
作者：
Panda, Shikshya S. [1 ]
Sahoo, Rajeev K. [1 ]
Patra, Sambit K. [1 ]
Biswal, Stuti [1 ]
Biswal, Bijesh K. [1 ]
机构：
[1] Natl Inst Technol Rourkela, Dept Life Sci, Canc Drug Resistance Lab, Rourkela 769008, Odisha, India
来源：
DRUG DISCOVERY TODAY | 2024年 / 29卷 / 08期
关键词：
Cancer; exosome; tumor microenvironment; tumor heterogeneity; metastasis; drug resistance; BREAST-CANCER; MACROPHAGES; SUPPRESSION; DELIVERY; CELLS;
D O I：
10.1016/j.drudis.2024.104061
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Exosomes play a pivotal part in cancer progression and metastasis by transferring various biomolecules. Recent research highlights their involvement in tumor microenvironment remodeling, mediating metastasis, tumor heterogeneity and drug resistance. The unique cargo carried by exosomes garners the interest of researchers owing to its potential as a stage-specific biomarker for early cancer detection and its role in monitoring personalized treatment. However, unanswered questions hinder a comprehensive understanding of exosomes and their cargo in this context. This review discusses recent advancements and proposes novel ideas for exploring exosomes in cancer progression, aiming to deepen our understanding and improve treatment approaches.
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收藏
页数：15
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