Optical Halo: A Proof of Concept for a New Broadband Microrheology Tool

被引:1
|
作者
Ramirez, Jorge [1 ]
Gibson, Graham M. [2 ]
Tassieri, Manlio [3 ]
机构
[1] Univ Politecn Madrid, Dept Ingn Quim, Jose Gutierrez Abascal 2, Madrid 28006, Spain
[2] Univ Glasgow, Adv Res Ctr, Sch Phys & Astron, Glasgow City G11 6EW, Scotland
[3] Univ Glasgow, Adv Res Ctr, James Watt Sch Engn, Div Biomed Engn, Glasgow City G11 6EW, Scotland
关键词
rheology; microrheology; optical tweezers; complex fluids; CONCENTRATED ISOTROPIC SOLUTIONS; SEMIFLEXIBLE POLYMERS; LIVING CELLS; VISCOELASTICITY; PARTICLE; TWEEZERS; RHEOLOGY; FORCE; MECHANICS; DYNAMICS;
D O I
10.3390/mi15070889
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Microrheology, the study of material flow at micron scales, has advanced significantly since Robert Brown's discovery of Brownian motion in 1827. Mason and Weitz's seminal work in 1995 established the foundation for microrheology techniques, enabling the measurement of viscoelastic properties of complex fluids using light-scattering particles. However, existing techniques face limitations in exploring very slow dynamics, crucial for understanding biological systems. Here, we present a proof of concept for a novel microrheology technique called "Optical Halo", which utilises a ring-shaped Bessel beam created by optical tweezers to overcome existing limitations. Through numerical simulations and theoretical analysis, we demonstrate the efficacy of the Optical Halo in probing viscoelastic properties across a wide frequency range, including low-frequency regimes inaccessible to conventional methods. This innovative approach holds promise for elucidating the mechanical behaviour of complex biological fluids.
引用
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页数:18
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