Scalable organocatalytic one pot asymmetric Strecker reaction via camphor sulfonyl functionalized crown-ether-tethered calix[4]arene

被引：1

作者：

Malik, Apoorva ^{[1
]}

Antil, Kirti ^{[1
]}

Singh, Nikhil ^{[1
]}

Sharma, Pragati R. ^{[1
]}

Sharma, Rakesh K. ^{[1
]}

机构：

[1] Indian Inst Technol Jodhpur, Dept Chem, Sustainable Mat & Catalysis Res Lab SMCRL, Jodhpur 342037, India

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 65期

关键词：

AMINO-ACID DERIVATIVES; MICHAEL ADDITION; CYANIDE; ALDIMINES; COMPLEXES; ALDEHYDES; EFFICIENT;

D O I：

10.1039/d4cc02674h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this communication, we designed a highly selective camphor sulfonyl functionalized crown-ether-tethered calix[4]arene-derived organocatalyst for asymmetric Strecker reaction to provide the desired cyano adducts in high yields (similar to 99.9% yield) and enantioselectivities (up to 99.3% ee). Furthermore, 2 step facile syntheses of the antiplatelet drug (S)-clopidogrel exemplify the potential of this method for the preparation of commercial compounds.

引用

页码：8561 / 8564

页数：4

共 7 条

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[7] Synthesis of Tetrahydroisoquinolin-4-Ones via Rh(II)-Catalyzed One-Pot Reaction of Aldehyde-Tethered N-Sulfonyl-1,2,3-Triazoles with Indoles
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