Long-Term Evaluation of Inserted Nanocomposite Hydrogel-Based Phosphorescent Oxygen Biosensors: Evolution of Local Tissue Oxygen Levels and Foreign Body Response

被引：0

作者：

Chimene, David ^{[1
]}

Saleem, Waqas ^{[1
]}

Longbottom, Nichole ^{[1
,2
]}

Ko, Brian ^{[1
]}

Jeevarathinam, Ananth Soundaram ^{[1
]}

Horn, Staci ^{[1
,2
]}

Mcshane, Michael J. ^{[1
,3
]}

机构：

[1] Texas A&M Univ, Dept Biomed Engn, College Stn, TX 77843 USA

[2] Texas A&M Univ, Dept Vet Anat & Pathobiol, College Stn, TX 77843 USA

[3] Texas A&M Univ, Dept Mat Sci & Engn, College Stn, TX 77843 USA

来源：

ACS APPLIED BIO MATERIALS | 2024年 / 7卷 / 06期

基金：

美国国家卫生研究院;

关键词：

biosensors; hydrogels; phosphorescence; in vivo; nanomaterials; biocompatibility; GLUCOSE SENSORS;

D O I：

10.1021/acsabm.4c00336

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Phosphorescence-based oxygen-sensing hydrogels are a promising platform technology for an upcoming generation of insertable biosensors that are smaller, softer, and potentially more biocompatible than earlier designs. However, much remains unknown about their long-term performance and biocompatibility in vivo. In this paper, we design and evaluate a range of hydrogel sensors that contain oxygen-sensitive phosphors stabilized by micro- and nanocarrier systems. These devices demonstrated consistently good performance and biocompatibility in young adult rats for over three months. This study thoroughly establishes the biocompatibility and long-term suitability of phosphorescence lifetime sensors in vivo, providing the groundwork for expansion of this platform technology into a family of small, unobtrusive biosensors for a range of clinically relevant metabolites.

引用

页码：3964 / 3980

页数：17