Endothelial ZIP8 plays a minor role in BMP6 regulation by iron in mice

被引：4

作者：

Fisher, Allison L. ^{[1
,2
]}

Phillips, Sydney ^{[1
,2
]}

Wang, Chia-Yu ^{[1
,2
]}

Paulo, Joao A. ^{[3
]}

Xiao, Xia ^{[1
,2
]}

Moschetta, Gillian A. ^{[1
,2
]}

Sridhar, Adhvaith ^{[1
,2
]}

Mancias, Joseph D. ^{[4
]}

Babitt, Jodie L. ^{[1
,2
,5
,6
]}

机构：

[1] Massachusetts Gen Hosp, Nephrol Div, Boston, MA USA

[2] Massachusetts Gen Hosp, Endocrine Unit, Boston, MA USA

[3] Harvard Med Sch, Dept Cell Biol, Boston, MA 02114 USA

[4] Harvard Med Sch, Dana Farber Canc Inst, Dept Radiat Oncol, Div Radiat & Genome Stabil, Boston, MA 02114 USA

[5] Harvard Med Sch, Massachusetts Gen Hosp, Nephrol Div, Thier Res Bldg 1123A,50 Blossom St, Boston, MA 02114 USA

[6] Harvard Med Sch, Massachusetts Gen Hosp, Endocrine Unit, Thier Res Bldg 1123A,50 Blossom St, Boston, MA 02114 USA

来源：

BLOOD | 2024年 / 143卷 / 23期

基金：

美国国家卫生研究院;

关键词：

LIVER; HOMEOSTASIS; EXPRESSION; OVERLOAD; SERUM;

D O I：

10.1182/blood.2023023385

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Iron-mediated induction of bone morphogenetic protein (BMP)6 expression by liver endothelial cells is essential for iron homeostasis regulation. We used multiple dietary and genetic mouse cohorts to demonstrate a minor functional role for the metal-ion transporter ZIP8 in regulating BMP6 expression under high-iron conditions.

引用

页码：2433 / 2437

页数：5

共 20 条

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PLOS ONE, 2014, 9 (01):
[10] Endothelial Bone Morphogenetic Protein 2 (Bmp2) Knockout Exacerbates Hemochromatosis in Homeostatic Iron Regulator (Hfe) Knockout Mice but not Bmp6 Knockout Mice
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