Targeting murine or human KLRG1 exerts potent anti-tumor efficacy involving both CD8T cells and NK cells

被引：0
|
作者：
Jones, Tyler A.
Sinicrope, Stephen
Yasuda, Kei
Pinkas, Jan
Gajewski, Thomas F.
机构：
来源：
CANCER RESEARCH | 2024年 / 84卷 / 06期
关键词：
D O I：
10.1158/1538-7445.AM2024-177
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
177
引用
收藏
页数：2
相关论文
共 50 条
  • [1] TGF-β downregulates KLRG1 expression in mouse and human CD8+ T cells
    Schwartzkopff, Sabrina
    Woyciechowski, Sandra
    Aichele, Ulrike
    Flecken, Tobias
    Zhang, Nu
    Thimme, Robert
    Pircher, Hanspeter
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2015, 45 (08) : 2212 - 2217
  • [2] Engineered NK-like NKG2C+CD8 T cells mediate superior anti-tumor efficacy over conventional CD8 T cells and NK cells
    Lupo, Kyle
    Panjwani, M. Kazim
    Daniyan, Anthony
    Klebanoff, Christopher
    Hsu, Katharine
    CANCER RESEARCH, 2024, 84 (06)
  • [3] Both CD8+ T cells and CD4+ T cells are essential in mediating potent anti-tumor immunity of DNA vaccines expressing cytosolic antigens
    Ji, H
    Chen, H
    Kurman, RJ
    Pardoll, DM
    Wu, TC
    LABORATORY INVESTIGATION, 1999, 79 (01) : 118A - 118A
  • [4] Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation
    Thimme, R
    Appay, V
    Koschella, M
    Panther, E
    Roth, E
    Hislop, AD
    Rickinson, AB
    Rowland-Jones, SL
    Blum, HE
    Pircher, H
    JOURNAL OF VIROLOGY, 2005, 79 (18) : 12112 - 12116
  • [5] Investigating the role of KLRG1 in regulatory T-cells and implications for anti-tumor immunity in Non-small Cell Lung Cancer
    Bag, Arup K.
    Schultz, Andrew R.
    Goala, Payal
    Karreth, Florian A.
    Adeegbe, Dennis O.
    JOURNAL OF IMMUNOLOGY, 2021, 206
  • [6] Interleukin-12 enhances the function and anti-tumor activity in murine and human CD8+ T cells
    Mark P. Rubinstein
    Ee Wern Su
    Samantha Suriano
    Colleen A. Cloud
    Kristina Andrijauskaite
    Pravin Kesarwani
    Kristina M. Schwartz
    Katelyn M. Williams
    C. Bryce Johnson
    Mingli Li
    Gina M. Scurti
    Mohamed L. Salem
    Chrystal M. Paulos
    Elizabeth Garrett-Mayer
    Shikhar Mehrotra
    David J. Cole
    Cancer Immunology, Immunotherapy, 2015, 64 : 539 - 549
  • [7] Interleukin-12 enhances the function and anti-tumor activity in murine and human CD8+ T cells
    Rubinstein, Mark P.
    Su, Ee Wern
    Suriano, Samantha
    Cloud, Colleen A.
    Andrijauskaite, Kristina
    Kesarwani, Pravin
    Schwartz, Kristina M.
    Williams, Katelyn M.
    Johnson, C. Bryce
    Li, Mingli
    Scurti, Gina M.
    Salem, Mohamed L.
    Paulos, Chrystal M.
    Garrett-Mayer, Elizabeth
    Mehrotra, Shikhar
    Cole, David J.
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2015, 64 (05) : 539 - 549
  • [8] Generating Potent Anti-Tumor CD62Lhigh CD8+T Cells for Adoptive Immunotherapy
    Yang, Shicheng
    Zhang, Ling
    Zheng, Zhili
    Park, Tristen
    Rosenberg, Steven A.
    Morgan, Richard A.
    JOURNAL OF IMMUNOTHERAPY, 2010, 33 (08) : 866 - 867
  • [9] KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity
    Herndler-Brandstetter, Dietmar
    Ishigame, Harumichi
    Shinnakasu, Ryo
    Plajer, Valerie
    Stecher, Carmen
    Zhao, Jun
    Lietzenmayer, Melanie
    Kroehling, Lina
    Takumi, Akiko
    Kometani, Kohei
    Inoue, Takeshi
    Kluger, Yuval
    Kaech, Susan M.
    Kurosaki, Tomohiro
    Okada, Takaharu
    Flavell, Richard A.
    IMMUNITY, 2018, 48 (04) : 716 - +
  • [10] Allogeneic dendritic cells induce potent antitumor immunity by activating KLRG1+CD8 T cells
    Wang, Chao
    Li, Zhengyuan
    Zhu, Zhongli
    Chai, Yijie
    Wu, Yiqing
    Yuan, Zhenglong
    Chang, Zhijie
    Wang, Zhao
    Zhang, Minghui
    SCIENTIFIC REPORTS, 2019, 9 (1)
12345