Examining the Efficacy and Safety of Combined Locoregional Therapy and Immunotherapy in Treating Hepatocellular Carcinoma
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作者:
Bajestani, Nojan
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Ohio State Univ, Coll Med, Columbus, OH 43210 USAOhio State Univ, Coll Med, Columbus, OH 43210 USA
Bajestani, Nojan
[1
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Wu, Gavin
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Ohio State Univ, Coll Med, Columbus, OH 43210 USAOhio State Univ, Coll Med, Columbus, OH 43210 USA
Wu, Gavin
[1
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Hussein, Ahmed
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Ohio State Univ, Coll Med, Columbus, OH 43210 USAOhio State Univ, Coll Med, Columbus, OH 43210 USA
Hussein, Ahmed
[1
]
Makary, Mina S.
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机构:
Ohio State Univ, Wexner Med Ctr, Dept Radiol, Div Vasc & Intervent Radiol, 395 W 12th Ave, Columbus, OH 43210 USAOhio State Univ, Coll Med, Columbus, OH 43210 USA
Makary, Mina S.
[2
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机构:
[1] Ohio State Univ, Coll Med, Columbus, OH 43210 USA
[2] Ohio State Univ, Wexner Med Ctr, Dept Radiol, Div Vasc & Intervent Radiol, 395 W 12th Ave, Columbus, OH 43210 USA
More than 800,000 people worldwide are diagnosed with HCC (hepatocellular carcinoma) each year, with approximately 700,000 deaths alone occurring in that same year. Treatment of HCC presents complex therapeutic challenges, particularly in intermediate and advanced stages. LRTs such as transarterial chemoembolization (TACE) and ablations have been the mainstay treatment for early to intermediate-stage HCC, and systemic therapies are used to treat intermediate-late-stage HCC. However, novel literature describing combining LRT with systemic therapies has shown promising results. This review explores recent advances in both liver-directed techniques for hepatocellular carcinoma, including bland transarterial embolization, chemoembolization, radioembolization, and ablative therapies in conjunction as well as with systemic therapies, with a focus on combination therapies, patient selection, procedural technique, periprocedural management, and outcomes. Our findings suggest that LRT combined with systemic therapies is a viable strategy for improving progression-free survival and time to progression for patients with intermediate-to-late-stage HCC. However, further investigation is required to refine treatment protocols and define patient cohorts that would benefit the most.
机构:
Yale Sch Med, Div Intervent Radiol, Dept Radiol & Biomed Imaging, New Haven, CT 06510 USAYale Sch Med, Div Intervent Radiol, Dept Radiol & Biomed Imaging, New Haven, CT 06510 USA
Dendy, Meaghan S.
Ludwig, Johannes M.
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Yale Sch Med, Div Intervent Radiol, Dept Radiol & Biomed Imaging, New Haven, CT 06510 USA
Univ Duisburg Essen, Univ Hosp Essen, Dept Diagnost & Intervent Radiol & Neuroradiol, Essen, GermanyYale Sch Med, Div Intervent Radiol, Dept Radiol & Biomed Imaging, New Haven, CT 06510 USA
Ludwig, Johannes M.
Stein, Stacey M.
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机构:
Yale Sch Med, Div Med Oncol, Dept Internal Med, New Haven, CT 06510 USA
Yale Sch Med, Yale Canc Ctr, 330 Cedar St,TE 2-224, New Haven, CT 06510 USAYale Sch Med, Div Intervent Radiol, Dept Radiol & Biomed Imaging, New Haven, CT 06510 USA
Stein, Stacey M.
Kim, Hyun S.
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机构:
Yale Sch Med, Div Intervent Radiol, Dept Radiol & Biomed Imaging, New Haven, CT 06510 USA
Yale Sch Med, Div Med Oncol, Dept Internal Med, New Haven, CT 06510 USA
Yale Sch Med, Yale Canc Ctr, 330 Cedar St,TE 2-224, New Haven, CT 06510 USAYale Sch Med, Div Intervent Radiol, Dept Radiol & Biomed Imaging, New Haven, CT 06510 USA
机构:
Univ Hong Kong, LKS Fac Med, Shenzhen Hosp, Dept Clin Oncol, Hong Kong, Peoples R China
Univ Hong Kong, Shenzhen Hosp, Hong Kong, Peoples R China
Univ Hong Kong, State Key Lab Liver Res, Hong Kong, Peoples R ChinaUniv Hong Kong, LKS Fac Med, Shenzhen Hosp, Dept Clin Oncol, Hong Kong, Peoples R China
Chiang, Chi Leung
Chan, Kenneth Sik Kwan
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Univ Hong Kong, LKS Fac Med, Shenzhen Hosp, Dept Clin Oncol, Hong Kong, Peoples R ChinaUniv Hong Kong, LKS Fac Med, Shenzhen Hosp, Dept Clin Oncol, Hong Kong, Peoples R China
Chan, Kenneth Sik Kwan
Chiu, Keith Wan Hang
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机构:
Univ Hong Kong, LKS Fac Med, Sch Clin Med, Dept Diag Radiol, Hong Kong, Peoples R China
Kwong Wah Hosp, Dept Diag & Intervent Radiol, Hong Kong, Peoples R ChinaUniv Hong Kong, LKS Fac Med, Shenzhen Hosp, Dept Clin Oncol, Hong Kong, Peoples R China
Chiu, Keith Wan Hang
Lee, Francis Ann Shing
论文数: 0引用数: 0
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机构:
Tuen Mun Hosp, Dept Clin Oncol, Hong Kong, Peoples R ChinaUniv Hong Kong, LKS Fac Med, Shenzhen Hosp, Dept Clin Oncol, Hong Kong, Peoples R China
Lee, Francis Ann Shing
Chen, Wenqi
论文数: 0引用数: 0
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机构:
Univ Hong Kong, Shenzhen Hosp, Clin Oncol Ctr, Hong Kong, Peoples R ChinaUniv Hong Kong, LKS Fac Med, Shenzhen Hosp, Dept Clin Oncol, Hong Kong, Peoples R China
Chen, Wenqi
Wong, Natalie Sean Man
论文数: 0引用数: 0
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机构:
Tuen Mun Hosp, Dept Clin Oncol, Hong Kong, Peoples R ChinaUniv Hong Kong, LKS Fac Med, Shenzhen Hosp, Dept Clin Oncol, Hong Kong, Peoples R China
Wong, Natalie Sean Man
Ho, Ryan Lok Man
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机构:
Gleneagles Hosp, Radiotherapy & Oncol Dept, Hong Kong, Peoples R ChinaUniv Hong Kong, LKS Fac Med, Shenzhen Hosp, Dept Clin Oncol, Hong Kong, Peoples R China
Ho, Ryan Lok Man
Lee, Venus Wan Yan
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机构:
Tuen Mun Hosp, Dept Clin Oncol, Med Phys Unit, Hong Kong, Peoples R ChinaUniv Hong Kong, LKS Fac Med, Shenzhen Hosp, Dept Clin Oncol, Hong Kong, Peoples R China
Lee, Venus Wan Yan
Man, Kwan
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机构:
Univ Hong Kong, LKS Fac Med, Sch Clin Med, Dept Surg, 102 Pokfulam Rd, Hong Kong 0000, Peoples R ChinaUniv Hong Kong, LKS Fac Med, Shenzhen Hosp, Dept Clin Oncol, Hong Kong, Peoples R China
Man, Kwan
Kong, Feng Ming
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机构:
Univ Hong Kong, LKS Fac Med, Shenzhen Hosp, Dept Clin Oncol, Hong Kong, Peoples R China
Univ Hong Kong, Shenzhen Hosp, Hong Kong, Peoples R ChinaUniv Hong Kong, LKS Fac Med, Shenzhen Hosp, Dept Clin Oncol, Hong Kong, Peoples R China
Kong, Feng Ming
Chan, Albert Chi Yan
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机构:
Univ Hong Kong, LKS Fac Med, Sch Clin Med, Dept Surg, 102 Pokfulam Rd, Hong Kong 0000, Peoples R China
Univ Hong Kong, State Key Lab Liver Res, Hong Kong, Peoples R ChinaUniv Hong Kong, LKS Fac Med, Shenzhen Hosp, Dept Clin Oncol, Hong Kong, Peoples R China
机构:
Guangxi Univ, Med Coll, Da Xue Dong Rd 100, Nanning 530004, Peoples R ChinaGuangxi Univ, Med Coll, Da Xue Dong Rd 100, Nanning 530004, Peoples R China
Zhang, Tingting
Chen, Jibing
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机构:
Jinan Univ, Fuda Canc Hosp, Guangzhou, Peoples R ChinaGuangxi Univ, Med Coll, Da Xue Dong Rd 100, Nanning 530004, Peoples R China
Chen, Jibing
Niu, Lizhi
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机构:
Jinan Univ, Fuda Canc Hosp, Guangzhou, Peoples R ChinaGuangxi Univ, Med Coll, Da Xue Dong Rd 100, Nanning 530004, Peoples R China
Niu, Lizhi
Liu, Yu
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机构:
Guangxi Univ, Med Coll, Da Xue Dong Rd 100, Nanning 530004, Peoples R ChinaGuangxi Univ, Med Coll, Da Xue Dong Rd 100, Nanning 530004, Peoples R China
Liu, Yu
Ye, Guangbin
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机构:
Guangxi Univ, Med Coll, Da Xue Dong Rd 100, Nanning 530004, Peoples R China
Youjiang Med Univ Nationalities, Baise, Peoples R ChinaGuangxi Univ, Med Coll, Da Xue Dong Rd 100, Nanning 530004, Peoples R China
Ye, Guangbin
Jiang, Minli
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机构:
Guangxi Univ, Med Coll, Da Xue Dong Rd 100, Nanning 530004, Peoples R ChinaGuangxi Univ, Med Coll, Da Xue Dong Rd 100, Nanning 530004, Peoples R China
Jiang, Minli
Qi, Zhongquan
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Guangxi Univ, Med Coll, Da Xue Dong Rd 100, Nanning 530004, Peoples R ChinaGuangxi Univ, Med Coll, Da Xue Dong Rd 100, Nanning 530004, Peoples R China
机构:
Med Univ S Carolina, Div Vasc & Intervent Radiol, Charleston, SC 29425 USAMed Univ S Carolina, Div Vasc & Intervent Radiol, Charleston, SC 29425 USA
Guimaraes, Marcelo
Uflacker, Renan
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Med Univ S Carolina, Div Vasc & Intervent Radiol, Charleston, SC 29425 USAMed Univ S Carolina, Div Vasc & Intervent Radiol, Charleston, SC 29425 USA