Equine-assisted service ' s effect on cartilage and skeletal biomarkers for adults and older adults with arthritis: A pilot study

Objective: The object of this study was to determine the effect of EAS (Equine -Assisted Services) on arthritis conditions, as measured by the sTnT (Skeletal troponin) and COMP (cartilage oligomeric matrix proteins) biomarkers, compared to an exercise attention control intervention. Design: This was a secondary analysis of a randomized clinical trial comparing equine -assisted therapy to exercise education attention -control on cartilage and skeletal biomarkers in adults with arthritis. Twenty-one adults ( M age = 64 years) with arthritis who attended rheumatology clinics in the midwestern United States participated. Results: No changes were found in sTnT from baseline to week six within either intervention nor were there differences in changes between the two groups ( p = 0.91). COMP increased from baseline to week six for both conditions, suggesting increased deterioration of cartilage and joints. Although the attention -control condition demonstrated larger increases in cartilage oligomeric matrix proteins level, compared to the EAS condition, these differences were not statistically ( p = 0.58) or clinically significant (i.e., trivial effect, d = - 0.16). When 3 outliers were removed, the differences in changes between EAT and attention -control group could be arguably of clinical significance ( d = - 0.33), suggesting that the attention -control group demonstrated larger increases in levels of COMP than those in the EAS condition, though this difference was not statistically significant ( p = 0.28). Conclusion: Although equine -assisted therapy may reduce pain and improve quality of life for adults with arthritis, findings here are not fully corroborated with biomarkers.