Mechanically skin-like and water-resistant self-healing bioelastomer for high-tension wound healing

被引：3

作者：

Huang, Jinyi ^{[1
,2
]}

Chen, Hongying ^{[1
]}

Jia, Zenghui ^{[1
,2
]}

Song, Xingqi ^{[1
]}

Wang, Sinan ^{[1
]}

Bai, Baoshuai ^{[1
]}

Wang, Jian ^{[1
]}

Zhang, Junfeng ^{[1
]}

Zhou, Guangdong ^{[1
,2
]}

Lei, Dong ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Cardiol,Shanghai Key Lab Tissue Engn,Dept Pla, Shanghai 200011, Peoples R China

[2] Shandong Second Med Univ, Res Inst Plast Surg, Weifang 261053, Shandong, Peoples R China

来源：

BIOACTIVE MATERIALS | 2024年 / 39卷

基金：

中国国家自然科学基金;

关键词：

Underwater self-healing; Dynamic bonds; Bioelastomer; High-tension wounds; Resveratrol; RESVERATROL; REPAIR; FILM;

D O I：

10.1016/j.bioactmat.2024.04.009

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The biomedical application of self-healing materials in wet or (under)water environments is quite challenging because the insulation and dissociation effects of water molecules significantly reduce the reconstruction of material -interface interactions. Rapid closure with uniform tension of high-tension wounds is often difficult, leading to further deterioration and scarring. Herein, a new type of thermosetting water-resistant self-healing bioelastomer (WRSHE) was designed by synergistically incorporating a stable polyglycerol sebacate (PGS) covalent crosslinking network and triple hybrid dynamic networks consisting of reversible disulfide metathesis (SS), and dimethylglyoxime urethane (Dou) and hydrogen bonds. And a resveratrol-loaded WRSHE (Res@WRSHE) was developed by a swelling, absorption, and crosslinked network locking strategy. WRSHEs exhibited skin -like mechanical properties in terms of nonlinear modulus behavior, biomimetic softness, high stretchability, and good elasticity, and they also achieved ultrafast and highly efficient self-healing in various liquid environments. For wound-healing applications of high-tension full-thickness skin defects, the convenient surface assembly by self-healing of WRSHEs provides uniform contraction stress to facilitate tight closure. Moreover, Res@WRSHEs gradually release resveratrol, which helps inflammatory response reduction, promotes blood vessel regeneration, and accelerates wound repair.

引用

页码：443 / 455

页数：13