Facile synthesis of 2-vinylindolines via a phosphine-mediated α-umpolung/Wittig olefination/cyclization cascade process

被引：6

作者：

Li, Shuhui ^{[1
]}

Xu, Dan ^{[1
]}

Yao, Hui ^{[1
,2
]}

Tan, Mengting ^{[1
]}

Li, Xiaoxuan ^{[1
]}

Liu, Mingguo ^{[1
]}

Wang, Long ^{[2
,3
]}

Huang, Nianyu ^{[1
,2
]}

Wang, Nengzhong ^{[1
,2
]}

机构：

[1] China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Hubei, Peoples R China

[2] Hubei Three Gorges Lab, Yichang 443007, Hubei, Peoples R China

[3] China Three Gorges Univ, Coll Mat & Chem Engn, Key Lab Inorgan Nonmet Crystalline & Energy Conver, Yichang 443002, Hubei, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 53期

基金：

中国国家自然科学基金;

关键词：

WITTIG OLEFINATION; REACTIVITY; DERIVATIVES; 1,3-DIENES;

D O I：

10.1039/d4cc01851f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel phosphine-mediated alpha-umpolung/Wittig olefination/cyclization cascade process between o-aminobenzaldehydes and Morita-Baylis-Hillman (MBH) carbonates has been ingeniously developed. This protocol serves as a practical tool for the facile synthesis of a broad range of 2-vinylindolines in moderate to good yields under mild reaction conditions. The applicability of this method was demonstrated with gram-scale reaction and various transformations of the corresponding product.

引用

页码：6773 / 6776

页数：4

共 32 条

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