Regulation of Cell Membrane Potential through Supramolecular System for Activating Calcium Ion Channels

被引：3
|
作者：
Song, Gang [1 ,2 ]
Li, Boying [3 ]
Yang, Zhiwen [1 ,2 ]
Lin, Hongrui [1 ,2 ]
Cheng, Junjie [1 ,2 ]
Huang, Yiming [1 ]
Xing, Chengfen [3 ]
Lv, Fengting [1 ]
Bai, Haotian [1 ]
Wang, Shu [1 ,2 ]
机构：
[1] Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Organ Solids, Inst Chem, Beijing 100190, Peoples R China
[2] Univ Chinese Acad Sci, Coll Chem, Beijing 100049, Peoples R China
[3] Hebei Univ Technol, Sch Chem Engn, Tianjin 300401, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2024年 / 146卷 / 36期
基金：
中国国家自然科学基金;
关键词：
VANILLOID RECEPTOR; CANCER; TRPV1; APOPTOSIS; VOLTAGE; REMOTE;
D O I：
10.1021/jacs.4c10710
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The regulation of the cell membrane potential plays a crucial role in governing the transmembrane transport of various ions and cellular life processes. However, in situ and on-demand modulation of cell membrane potential for ion channel regulation is challenging. Herein, we have constructed a supramolecular assembly system based on water-soluble cationic oligo(phenylenevinylene) (OPV) and cucurbit[7]uril (CB[7]). The controllable disassembly of OPV/4CB[7] combined with the subsequent click reaction provides a step-by-step adjustable surface positive potential. These processes can be employed in situ on the plasma membrane to modulate the membrane potential on-demand for precisely controlling the activation of the transient receptor potential vanilloid 1 (TRPV1) ion channel and up-regulating exogenous calcium-responsive gene expression. Compared with typical optogenetics, electrogenetics, and mechanogenetics, our strategy provides a perspective supramolecular genetics toolbox for the regulation of membrane potential and downstream intracellular gene regulation events.
引用
收藏
页码：25383 / 25393
页数：11
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