Correlation between pupillary size and depth of focus after the implantation of extended depth of focus intraocular lenses

PurposeTo evaluate whether depth of focus after the implantation of extended depth of focus (EDoF) intraocular lenses (IOLs) correlates with pupillary size.MethodsThis retrospective case series study evaluated eyes undergoing cataract surgery with implantation of EDoF IOLs. At least one month postoperatively, the depth of focus (DoF) was measured to determine the correlation with pupillary size, age, anterior chamber depth (ACD), axial length (AXL), and corneal spherical aberrations (SA).ResultsThe study evaluated 64 eyes of 49 patients. The mean depth of focus was 2.67 diopters (D). The mean preoperative photopic pupil size was 3.36 mm. A significant negative association was found between preoperative photopic pupil size and depth of focus (r = 0.30, Pearson's correlation coefficient) and between preoperative mesopic pupil size and depth of focus (r = 0.274, Pearson's correlation coefficient). What is known:center dot Optical and visual performance of a multifocal IOL likely depends on pupil size.What is new:center dot Smaller pupil size (including preoperative photopic, mesopic pupil size) had strong association with good post-operative depth of focus, with Extended Depth of Focus Intraocular Lenses.center dot No significant correlation was observed between age, anterior chamber depth, axial length, corneal spherical aberra?tions, and depth of focus in the Extended Depth of Focus Intraocular Lenses.